Back to search

Peptide record

TPDB00846

peptide derived from bovine kappa-casein (28-30) ACE inhibitors Antibacterial Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB00846
peptide derived from bovine kappa-casein (28-30)
ACE inhibitors Antibacterial Antihypertensive Antioxidant
Anti-infective peptides Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
IQY
Physicochemical Analysis
C20H30N4O6
ARNDCEGHLKMFPSTWV
QIY
422.48
5.94
0
0
2
-0
-0.67
-0.100
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
352.68
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
3
C20H30N4O6
422.48
5.94
-0
-0.67
-0.100
422.4742
422.2158
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
70.40 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Lopez-Exposito I., Quiros A., Amigo L., Recio I.
Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides. Lait, 87 (2007), 241–249.
2007
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C20H30N4O6/c1-3-11(2)17(22)19(28)23-14(8-9-16(21)26)18(27)24-15(20(29)30)10-12-4-6-13(25)7-5-12/h4-7,11,14-15,17,25H,3,8-10,22H2,1-2H3,(H2,21,26)(H,23,28)(H,24,27)(H,29,30)/t11-,14-,15-,17-/m0/s1 InChIKey=HTDRTKMNJRRYOJ-SIUGBPQLSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8149) the DFBP database the MBPDB database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8267) the DFBP database the EROP-Moscow database the MBPDB database Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) Peptide obtained by hydrolysis of bovine kappa-casein by use of porcine pepsin A.
Evidence 2 Activity

Activity

IC50
Antihypertensive
70.40 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Lopez-Exposito I., Quiros A., Amigo L., Recio I.
Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides. Lait, 87 (2007), 241–249.
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)O InChI=1S/C20H30N4O6/c1-3-11(2)17(22)19(28)23-14(8-9-16(21)26)18(27)24-15(20(29)30)10-12-4-6-13(25)7-5-12/h4-7,11,14-15,17,25H,3,8-10,22H2,1-2H3,(H2,21,26)(H,23,28)(H,24,27)(H,29,30)/t11-,14-,15-,17-/m0/s1 InChIKey=HTDRTKMNJRRYOJ-SIUGBPQLSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8149) the DFBP database the MBPDB database Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8267) the DFBP database the EROP-Moscow database the MBPDB database Activator of Angiotensin 2-converting enzyme (ACE2) (EC 3.4.17.23) (MEROPS ID: M02.006) Peptide obtained by hydrolysis of bovine kappa-casein by use of porcine pepsin A.
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3