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Peptide record

TPDB00845

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB00845
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
IQW
Physicochemical Analysis
C22H31N5O5
ARNDCEGHLKMFPSTYV
QIW
445.52
6.02
0
0
2
-0
-1.58
0.033
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
1234.52
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C22H31N5O5
445.52
6.02
-0
-1.58
0.033
445.5108
445.2318
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Majumder K., Chakrabarti S., Morton J.S., Panahi S., Kaufman S., Davidge S.T., Wu J.
Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats. Food Chem.,13, 50-60, 2015
2015
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@](C(N[C@](C(N[C@](C(O)=O)(Cc1c2ccccc2[nH]c1)[H])=O)(CCC(N)=O)[H])=O)([C@@H](C)CC)[H] InChI=1S/C22H31N5O5/c1-3-12(2)19(24)21(30)26-16(8-9-18(23)28)20(29)27-17(22(31)32)10-13-11-25-15-7-5-4-6-14(13)15/h4-7,11-12,16-17,19,25H,3,8-10,24H2,1-2H3,(H2,23,28)(H,26,30)(H,27,29)(H,31,32)/t12-,16-,17-,19-/m0/s1 InChIKey: MVLDERGQICFFLL-ZQINRCPSSA-N Peptide reveals blond pressure lowering activity in vivo. Majumder K., Chakrabarti S., Morton J.S., Panahi S., Kaufman S., Davidge S.T., Wu J., 2015, Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats. Food Chem., 13, 50-60 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9161)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Majumder K., Chakrabarti S., Morton J.S., Panahi S., Kaufman S., Davidge S.T., Wu J.
Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats. Food Chem.,13, 50-60, 2015
2015
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@](C(N[C@](C(N[C@](C(O)=O)(Cc1c2ccccc2[nH]c1)[H])=O)(CCC(N)=O)[H])=O)([C@@H](C)CC)[H] InChI=1S/C22H31N5O5/c1-3-12(2)19(24)21(30)26-16(8-9-18(23)28)20(29)27-17(22(31)32)10-13-11-25-15-7-5-4-6-14(13)15/h4-7,11-12,16-17,19,25H,3,8-10,24H2,1-2H3,(H2,23,28)(H,26,30)(H,27,29)(H,31,32)/t12-,16-,17-,19-/m0/s1 InChIKey: MVLDERGQICFFLL-ZQINRCPSSA-N Peptide reveals blond pressure lowering activity in vivo. Majumder K., Chakrabarti S., Morton J.S., Panahi S., Kaufman S., Davidge S.T., Wu J., 2015, Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats. Food Chem., 13, 50-60 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9161)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3