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Peptide record

TPDB00840

ACE inhibitor (from bovine beta-CN) Anti-inflammatory peptide ACE inhibitors Anti-inflammatory Antihypertensive Antioxidant Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB00840
ACE inhibitor (from bovine beta-CN) Anti-inflammatory peptide
ACE inhibitors Anti-inflammatory Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Immunity and inflammation peptides Neuroactive peptides Functional / health-promoting peptides
FermFooDB Peptipedia AHTPDB AHTpin AODB
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Anti-inflammatory, Antihypertensive, and other sources) peptide sequence curated from FermFooDB, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
IPP
Physicochemical Analysis
C16H27N3O4
ARNDCEQGHLKMFSTWYV
P
325.41
6.02
0
0
1
-0
0.59
0.433
130.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C16H27N3O4
325.41
6.02
-0
0.59
0.433
325.4022
325.1995
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
5.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Nakamura Y., Yamamoto N., Sakai K., Yamazaki S., Takano T.
Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J. Dairy Sci., 78, 777-783, 1995
1995
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C16H27N3O4/c1-3-10(2)13(17)15(21)18-8-4-6-11(18)14(20)19-9-5-7-12(19)16(22)23/h10-13H,3-9,17H2,1-2H3,(H,22,23)/t10-,11-,12-,13-/m0/s1 InChIKey=FQYQMFCIJNWDQZ-CYDGBPFRSA-N Review concerning the peptide: Li S., Bu T., Zheng J., Liu L., He G., Wu J., 2019, Preparation, bioavailability, and mechanism of emerging activities of Ile-Pro-Pro and Val-Pro-Pro. Compr. Rev. Food Sci. Food Saf., 18, 1097-1110 Antiinflammatory peptide according to the MBPDB database the BIOPEP-UWM database of bioactive peptides (ID 9537) Inhibitor of the Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BRENDA database
Evidence 2 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
Inhibitor of inflammation
anti inflammatory
ai

Source & Reference

NA
Chakrabarti S., Wu J.
Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) promote adipocyte differentiation and inhibit inflammation in 3T3-F442A cells. PLoS ONE, 10, Article No e0117492, 2015
2015
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C16H27N3O4/c1-3-10(2)13(17)15(21)18-8-4-6-11(18)14(20)19-9-5-7-12(19)16(22)23/h10-13H,3-9,17H2,1-2H3,(H,22,23)/t10-,11-,12-,13-/m0/s1 InChIKey=FQYQMFCIJNWDQZ-CYDGBPFRSA-N Review concerning the peptide: Li S., Bu T., Zheng J., Liu L., He G., Wu J., 2019, Preparation, bioavailability, and mechanism of emerging activities of Ile-Pro-Pro and Val-Pro-Pro. Compr. Rev. Food Sci. Food Saf., 18, 1097-1110 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 3522) the ChEMBL database the EROP-Moscow database the MBPDB database Inhibitor of the Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BRENDA database
Evidence 3 Activity

Activity

IC50
Antihypertensive
5.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Nakamura Y., Yamamoto N., Sakai K., Yamazaki S., Takano T.
Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J. Dairy Sci., 78, 777-783, 1995
1995
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(N)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(O)=O InChI=1S/C16H27N3O4/c1-3-10(2)13(17)15(21)18-8-4-6-11(18)14(20)19-9-5-7-12(19)16(22)23/h10-13H,3-9,17H2,1-2H3,(H,22,23)/t10-,11-,12-,13-/m0/s1 InChIKey=FQYQMFCIJNWDQZ-CYDGBPFRSA-N Review concerning the peptide: Li S., Bu T., Zheng J., Liu L., He G., Wu J., 2019, Preparation, bioavailability, and mechanism of emerging activities of Ile-Pro-Pro and Val-Pro-Pro. Compr. Rev. Food Sci. Food Saf., 18, 1097-1110 Antiinflammatory peptide according to the MBPDB database the BIOPEP-UWM database of bioactive peptides (ID 9537) Inhibitor of the Angiotensin 2-converting enzyme (EC 3.4.17.23) (MEROPS ID: M02.006) according to the BRENDA database
Additional Detail Fields 1 fields
3