TPDB

3D PDB MODEL

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TPDB ID TPDB00832

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

IPAGM

FASTA

>TPDB00832|ACE inhibitors;Antioxidant|length=5
IPAGM

Formula C21H37N5O6S1

Absent Amino Acids RNDCEQHLKFSTWYV

Common Amino Acids AGIMP

Mass 487.61

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 3

Net Charge -0

Boman Index -0.25

Hydrophobicity 1.240

Aliphatic Index 98.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

0

K

1

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

5

Formula

C21H37N5O6S1

Mass

487.61

PI

6.02

Net Charge

-0

Boman Index

-0.25

Hydrophobicity

1.240

Chemical_Mass

487.6130

Monoisotopic_Mass

487.2456

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Girgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.

Title

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384–394.

Year 2014

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C)C(=O)NCC(=O)N[C@@]([H])(CCSC)C(=O)O InChI= 1S/C21H37N5O6S/c1-5-12(2)17(22)20(30)26-9-6-7-15(26)19(29)24-13(3)18(28)23-11-16(27)25-14(21(31)32)8-10-33-4/h12-15,17H,5-11,22H2,1-4H3,(H,23,28)(H,24,29)(H,25,27)(H,31,32)/t12-,13-,14-,15-,17-/m0/s1 InChIKey: YKEZKFOJCMMKGC-BWJWTDLKSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive pepeptides (ID 9986) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive pepeptides (ID 9988)

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb

Source DFBP

Number_of_Residues

5