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Peptide record

TPDB00831

ACE inhibitor (beta-LG fr. 78-80) Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB00831
ACE inhibitor (beta-LG fr. 78-80) Dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antihypertensive Antioxidant Neuropeptide iDPPIV
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP iDPPIV
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
IPA
Physicochemical Analysis
C14H25N3O4
RNDCEQGHLKMFSTWYV
AIP
299.37
6.02
0
0
2
-0
-0.03
1.567
163.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C14H25N3O4
299.37
6.02
-0
-0.03
1.567
299.3650
299.1839
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
141.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81 (12), 3131-3138 (1998)
1998
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)C)CCC1)[C@H](CC)C InChI=1S/C14H25N3O4/c1-4-8(2)11(15)13(19)17-7-5-6-10(17)12(18)16-9(3)14(20)21/h8-11H,4-7,15H2,1-3H3,(H,16,18)(H,20,21)/t8-,9-,10-,11-/m0/s1 InChIKey: IITVUURPOYGCTD-NAKRPEOUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8304) the MBPDB database Antihypertensive peptide according to the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
Antihypertensive
141.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J. Dairy Sci., 81 (12), 3131-3138 (1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)C)CCC1)[C@H](CC)C InChI=1S/C14H25N3O4/c1-4-8(2)11(15)13(19)17-7-5-6-10(17)12(18)16-9(3)14(20)21/h8-11H,4-7,15H2,1-3H3,(H,16,18)(H,20,21)/t8-,9-,10-,11-/m0/s1 InChIKey: IITVUURPOYGCTD-NAKRPEOUSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8304) the MBPDB database Antihypertensive peptide according to the EROP-Moscow database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Evidence 4 Activity

Activity

IC50
iDPPIV
49.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Tulipano G., Sibilia V., Caroli A. M., Cocchi D.
Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors. Peptides, 32, 835-838, 2011
2011
Journal

Other

3
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)O)C)CCC1)[C@H](CC)C InChI=1S/C14H25N3O4/c1-4-8(2)11(15)13(19)17-7-5-6-10(17)12(18)16-9(3)14(20)21/h8-11H,4-7,15H2,1-3H3,(H,16,18)(H,20,21)/t8-,9-,10-,11-/m0/s1 InChIKey: IITVUURPOYGCTD-NAKRPEOUSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003 Another reference concerning peptide: Lacroix I. M. E., Li-Chan E. C. Y., 2012, Evaluation of the potential of dietary proteins as precursors of dipeptidyl peptidase (DPP)-IV inhibitors by an in silico approach. J. Funct. Foods, 4, 403-422 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 3507) the MBPDB database Antihypertensive peptide according to the EROP-Moscow database
Additional Detail Fields 1 fields
3