TPDB

3D PDB MODEL

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TPDB ID TPDB00818

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

IIAPPER

FASTA

>TPDB00818|ACE inhibitors;Antioxidant|length=7
IIAPPER

Formula C36H62N10O10

Absent Amino Acids NDCQGHLKMFSTWYV

Common Amino Acids IP

Mass 794.95

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 3

Net Charge -0

Boman Index 2.94

Hydrophobicity -0.057

Aliphatic Index 125.71

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

1

R

0

N

0

D

0

C

1

E

0

Q

0

G

0

H

2

I

0

L

0

K

0

M

0

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

7

Formula

C36H62N10O10

Mass

794.95

PI

6.97

Net Charge

-0

Boman Index

2.94

Hydrophobicity

-0.057

Chemical_Mass

794.9360

Monoisotopic_Mass

794.4636

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 8.72 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)O InChI=1S/C36H62N10O10/c1-6-19(3)27(37)31(51)44-28(20(4)7-2)32(52)41-21(5)33(53)46-18-10-13-25(46)34(54)45-17-9-12-24(45)30(50)42-22(14-15-26(47)48)29(49)43-23(35(55)56)11-8-16-40-36(38)39/h19-25,27-28H,6-18,37H2,1-5H3,(H,41,52)(H,42,50)(H,43,49)(H,44,51)(H,47,48)(H,55,56)(H4,38,39,40)/t19-,20-,21-,22-,23-,24-,25-,27-,28-/m0/s1 InChIKey=ZHQCNOJJTASHDW-ADWUDYDCSA-N Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9816) Inhibitor of Alpha-amylase (EC 3.2.1.1) to the BIOPEP-UWM database of bioactive peptides (ID 9817)

Number_of_Residues

7