TPDB

3D PDB MODEL

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TPDB ID TPDB00804

Peptide_Name

Anti-inflammatory peptide

Activity

Anti-inflammatory Antioxidant

Activity_category_statistics

Immunity and inflammation peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 8-aa standard natural multi-activity (Anti-inflammatory and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

IGFLIIWV

FASTA

>TPDB00804|Anti-inflammatory;Antioxidant|length=8
IGFLIIWV

Formula C51H77N9O9

Absent Amino Acids ARNDCEQHKMPSTY

Common Amino Acids I

Mass 960.23

PI 6.02

Basic Residues 0

Acidic Residues 0

Hydrophobic Residues 7

Net Charge -0

Boman Index -4.39

Hydrophobicity 2.875

Aliphatic Index 231.25

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 572.78

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

1

G

0

H

3

I

1

L

0

K

0

M

1

F

0

P

0

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1

Length

8

Formula

C51H77N9O9

Mass

960.23

PI

6.02

Net Charge

-0

Boman Index

-4.39

Hydrophobicity

2.875

Chemical_Mass

960.2089

Monoisotopic_Mass

959.5826

Evidence 1 Activity

Activity

Activity Endpoint EC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Function Anti-inflammatory

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Cruz-Chamorro I., Santos-Sánchez G., Bollati C., Bartolomei M., Li J., Arnoldi A., Lammi C.

Title

Hempseed (Cannabis sativa) peptides WVSPLAGRT and IGFLIIWV exert anti-inflammatory activity in the LPS-stimulated human hepatic cell line. J. Agric. Food Chem., 70, 577–583, 2022

Year 2022

Literature Source Journal

Other

Number of Residues 8

Additional Info

BIOPEP-UWM database of bioactive peptids SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C51H77N9O9/c1-11-30(8)41(52)48(65)54-27-40(61)55-38(24-33-19-15-14-16-20-33)45(62)56-37(23-28(4)5)46(63)59-44(32(10)13-3)50(67)60-43(31(9)12-2)49(66)57-39(47(64)58-42(29(6)7)51(68)69)25-34-26-53-36-22-18-17-21-35(34)36/h14-22,26,28-32,37-39,41-44,53H,11-13,23-25,27,52H2,1-10H3,(H,54,65)(H,55,61)(H,56,62)(H,57,66)(H,58,64)(H,59,63)(H,60,67)(H,68,69)/t30-,31-,32-,37-,38-,39-,41-,42-,43-,44-/m0/s1 InChIKey=MJORDOLVTASVCE-SLYZAHRVSA-N

Number_of_Residues

8