TPDB

3D PDB MODEL

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TPDB ID TPDB00784

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 5-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

HYVPV

FASTA

>TPDB00784|ACE inhibitors;Antioxidant|length=5
HYVPV

Formula C30H43N7O7

Absent Amino Acids ARNDCEQGILKMFSTW

Common Amino Acids V

Mass 613.71

PI 7.77

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 3

Net Charge +0

Boman Index 0.61

Hydrophobicity 0.460

Aliphatic Index 116.00

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 242.78

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

0

L

0

K

0

M

0

F

1

P

0

S

0

T

0

W

1

Y

2

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 2

Length

5

Formula

C30H43N7O7

Mass

613.71

PI

7.77

Net Charge

+0

Boman Index

0.61

Hydrophobicity

0.460

Chemical_Mass

613.7034

Monoisotopic_Mass

613.3214

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 998.20 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Torkova A., Kononikhin A., Bugrova A., Khotchenkov V., Tsentalovich M., Medvedeva U.

Title

Effect of in vitro gastrointestinal digestion on bioactivity of poultry protein hydrolysate. Curr. Res. Nutr. Food Sci., 4 (SI 2), 77-86, 2016

Year 2016

Literature Source Journal

Other

Number of Residues 5

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(Cc1ccc(O)cc1)C(=O)N[C@@]([H])(C(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C30H43N7O7/c1-16(2)24(29(42)37-11-5-6-23(37)28(41)36-25(17(3)4)30(43)44)35-27(40)22(12-18-7-9-20(38)10-8-18)34-26(39)21(31)13-19-14-32-15-33-19/h7-10,14-17,21-25,38H,5-6,11-13,31H2,1-4H3,(H,32,33)(H,34,39)(H,35,40)(H,36,41)(H,43,44)/t21-,22-,23-,24-,25-/m0/s1 InChIKey: OWUGAPDRZCZVSY-KEOOTSPTSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9084)

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB AoXpDb

Source DFBP

Number_of_Residues

5