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Peptide record

TPDB00764

ACE inhibitor Hypotensive peptide ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB00764
ACE inhibitor Hypotensive peptide
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AODB AoXpDb Multi-AOP
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
HPHPHLSF
Physicochemical Analysis
C46H62N14O10
ARNDCEQGIKMTWYV
H
971.09
8.09
3
0
2
+0
2.22
-0.875
48.75
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
1
L
0
K
0
M
1
F
2
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 1 K: 0 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C46H62N14O10
971.09
8.09
+0
2.22
-0.875
971.0698
970.4760
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Gómez-Ruiz J. Á, Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 22, 4202-4211, 2007
2007
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C46H62N14O10/c1-26(2)14-32(39(62)58-36(22-61)41(64)57-35(46(69)70)15-27-8-4-3-5-9-27)54-40(63)33(17-29-20-49-24-52-29)55-42(65)38-11-7-13-60(38)45(68)34(18-30-21-50-25-53-30)56-43(66)37-10-6-12-59(37)44(67)31(47)16-28-19-48-23-51-28/h3-5,8-9,19-21,23-26,31-38,61H,6-7,10-18,22,47H2,1-2H3,(H,48,51)(H,49,52)(H,50,53)(H,54,63)(H,55,65)(H,56,66)(H,57,64)(H,58,62)(H,69,70)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey=CAUGYGWAFDJIGN-QSVFAHTRSA-N Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10251) the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10254) the DFBP database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10256) the DFBP database the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Gómez-Ruiz J. Á, Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 22, 4202-4211, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C46H62N14O10/c1-26(2)14-32(39(62)58-36(22-61)41(64)57-35(46(69)70)15-27-8-4-3-5-9-27)54-40(63)33(17-29-20-49-24-52-29)55-42(65)38-11-7-13-60(38)45(68)34(18-30-21-50-25-53-30)56-43(66)37-10-6-12-59(37)44(67)31(47)16-28-19-48-23-51-28/h3-5,8-9,19-21,23-26,31-38,61H,6-7,10-18,22,47H2,1-2H3,(H,48,51)(H,49,52)(H,50,53)(H,54,63)(H,55,65)(H,56,66)(H,57,64)(H,58,62)(H,69,70)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey=CAUGYGWAFDJIGN-QSVFAHTRSA-N Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10251) the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10254) the DFBP database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10256) the DFBP database the MBPDB database
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Lowering blood pressure in rats
hypotensive
hyp

Source & Reference

AHTPDB
Miguel M., Gómez-Ruiz J. Á., Recio I., Aleixandre A.
Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats. Mol. Nutr. Food Res., 54, 1422-1447, 2010
2010
Journal

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CN=C[NH]1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CO)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C46H62N14O10/c1-26(2)14-32(39(62)58-36(22-61)41(64)57-35(46(69)70)15-27-8-4-3-5-9-27)54-40(63)33(17-29-20-49-24-52-29)55-42(65)38-11-7-13-60(38)45(68)34(18-30-21-50-25-53-30)56-43(66)37-10-6-12-59(37)44(67)31(47)16-28-19-48-23-51-28/h3-5,8-9,19-21,23-26,31-38,61H,6-7,10-18,22,47H2,1-2H3,(H,48,51)(H,49,52)(H,50,53)(H,54,63)(H,55,65)(H,56,66)(H,57,64)(H,58,62)(H,69,70)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey=CAUGYGWAFDJIGN-QSVFAHTRSA-N Osteoanabolic peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10251) the MBPDB database Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 10255) the DFBP database the MBPDB database Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10254 the DFBP database
Evidence 4 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
8