TPDB

3D PDB MODEL

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TPDB ID TPDB00747

Peptide_Name

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)

Activity

ACE inhibitors Antihypertensive Antioxidant iDPPIV

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP iDPPIV

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.

Sequence

HL

FASTA

>TPDB00747|ACE inhibitors;Antihypertensive;Antioxidant;iDPPIV|length=2
HL

Formula C12H20N4O3

Absent Amino Acids ARNDCEQGIKMFPSTWYV

Common Amino Acids HL

Mass 268.32

PI 7.85

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 1

Net Charge +0

Boman Index 0.40

Hydrophobicity 0.300

Aliphatic Index 195.00

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

1

H

0

I

1

L

0

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

2

Formula

C12H20N4O3

Mass

268.32

PI

7.85

Net Charge

+0

Boman Index

0.40

Hydrophobicity

0.300

Chemical_Mass

268.3114

Monoisotopic_Mass

268.1531

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 3200.00 µM

Function Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Cushman D. W.

Title

Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.

Year 1981

Literature Source book

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)/t9-,10-/m0/s1 InChIKey=MMFKFJORZBJVNF-UWVGGRQHSA-N Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9483) the BRENDA database Inhibitor of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8557) Antioxidative peptide acoording to the BIOPEP-UWM database of bioactive peptides (ID 3317)

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 3200.00 µM

Function Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Cushman D. W.

Title

Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.

Year 1981

Literature Source book

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)/t9-,10-/m0/s1 InChIKey=MMFKFJORZBJVNF-UWVGGRQHSA-N Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9483) the BRENDA database Inhibitor of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8557) Antioxidative peptide acoording to the BIOPEP-UWM database of bioactive peptides (ID 3317)

Evidence 3 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity iDPPIV

Activity Measurement 143.19 µM

Function Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)

Detail Activity dipeptidyl peptidase IV inhibitor

Activity Code dpp

Source & Reference

Database Source iDPPIV

Authors Nongonierma A. B., Mooney C., Shields D. C., FitzGerald R. J.

Title Inhibition of dipeptidyl peptidase IV and xanthine oxidase by amino acids and dipeptides. Food Chemistry, 141, 644-653.

Year 2013

Literature Source Journal

Other

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)/t9-,10-/m0/s1 InChIKey=MMFKFJORZBJVNF-UWVGGRQHSA-N Inhibitor of Dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9483) the BRENDA database Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the BindingDB database, the BIOPEP-UWM database of bioactive peptides (ID 7602), the ChEMBL database, the EROP-Moscow database Antioxidative peptide acoording to the BIOPEP-UWM database of bioactive peptides (ID 3317)

Number_of_Residues

2