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Peptide record

TPDB00742

ACE inhibitor Antioxidative peptide ACE inhibitors Antidiabetic Antihypertensive Antioxidant standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB00742
ACE inhibitor Antioxidative peptide
ACE inhibitors Antidiabetic Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AODB Multi-AOP
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antidiabetic, Antihypertensive, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AODB, and other sources, with an available 3D structural model.
Sequence
HK
Physicochemical Analysis
C12H21N5O3
ARNDCEQGILMFPSTWYV
HK
283.33
10.10
2
0
0
+1
1.95
-3.550
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C12H21N5O3
283.33
10.10
+1
1.95
-3.550
283.3260
10.04
283.1640
0.00
N[C@@]([H])(CC1=CN=C-N1)C(=O)N[C@@]([H])(CCCCN)C(=O)O
283.33 Da
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C12H21N5O3/c13-4-2-1-3-10(12(19)20)17-11(18)9(14)5-8-6-15-7-16-8/h6-7,9-10H,1-5,13-14H2,(H,15,16)(H,17,18)(H,19,20)/t9-,10-/m0/s1 InChIKey=CZVQSYNVUHAILZ-UWVGGRQHSA-N Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9494)
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
van Platerink C. J., Janssen H.-G. M., Haverkamp J.
Application of at-line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates. Anal. Bioanal. Chem., 2008, 391, 299-307.
2008
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C12H21N5O3/c13-4-2-1-3-10(12(19)20)17-11(18)9(14)5-8-6-15-7-16-8/h6-7,9-10H,1-5,13-14H2,(H,15,16)(H,17,18)(H,19,20)/t9-,10-/m0/s1 InChIKey=CZVQSYNVUHAILZ-UWVGGRQHSA-N Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9494)
Evidence 3 Activity

Activity

Antioxidative activity
ACE-inhibitory activity
This peptide yielded antioxidative activity against linoleic acid in an aqueous system at pH 7.0 (data not shown).
Literature report: N.D Prediction: ToxinPred
Antioxidant

Assay & Model

linoleic acid peroxidation
Enzymatic hydrolysis
Hydrolyzed with Amano S (from Bacillus subtilis)

Source & Reference

AODB
Tsuge, N., Eikawa, Y., Nomura, Y., Yamamoto, M., Sugisawa, K. Antioxidative Activity of Peptides Prepared by Enzymatic Hydrolysis of Egg-white Albumin. Journal of the agricultural chemical society of Japan. 1991, 65, 1635-41.
10.1271/nogeikagaku1924.65.1635
No data
1991
DFBP

Other

Native peptide
Animal
Egg
Egg white albumin
Additional Detail Fields 1 fields
2