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Peptide record

TPDB00741

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB00741
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
HIR
Physicochemical Analysis
C18H32N8O4
ANDCEQGLKMFPSTWYV
RHI
424.50
11.05
2
0
1
+1
1.46
-1.067
130.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C18H32N8O4
424.50
11.05
+1
1.46
-1.067
424.4966
424.2540
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
955.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

3
BIOPEP database of bioactive peptides SMILES: N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C18H32N8O4/c1-3-10(2)14(26-15(27)12(19)7-11-8-22-9-24-11)16(28)25-13(17(29)30)5-4-6-23-18(20)21/h8-10,12-14H,3-7,19H2,1-2H3,(H,22,24)(H,25,28)(H,26,27)(H,29,30)(H4,20,21,23)/t10-,12-,13-,14-/m0/s1 InChIKey: JJHWJUYYTWYXPL-PYJNHQTQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
955.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wu J., Aluko R. E., Nakai S.
Structural requirements of angiotensin I-converting enzyme inhibitory activity: quantitative structure-activity relationship study of di- and tripeptides. J. Agric. Food Chem., 54, 732-738, 2006
2006
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP database of bioactive peptides SMILES: N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O InChI=1S/C18H32N8O4/c1-3-10(2)14(26-15(27)12(19)7-11-8-22-9-24-11)16(28)25-13(17(29)30)5-4-6-23-18(20)21/h8-10,12-14H,3-7,19H2,1-2H3,(H,22,24)(H,25,28)(H,26,27)(H,29,30)(H4,20,21,23)/t10-,12-,13-,14-/m0/s1 InChIKey: JJHWJUYYTWYXPL-PYJNHQTQSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3