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Peptide record

TPDB00688

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB00688
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB Multi-AOP
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
GTW
Physicochemical Analysis
C17H22N4O5
ARNDCEQHILKMFPSYV
GTW
362.39
6.02
0
0
1
-0
-1.70
-0.667
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
1517.72
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
3
C17H22N4O5
362.39
6.02
-0
-1.70
-0.667
362.3795
362.1585
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
464.60 µM
Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Chen G. W., Tsai J. S., Pan B. S.
Purification of angiotensin I-converting inhibitory peptides and antihypertensive effect of milk produced by protease-facilitate lactic fermentation. Int. Dairy J., 2007, 17, 641-647
2007
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1c[nH]c2ccccc12)(NC(=O)[C@@]([H])(NC(=O)CN)[C@@H](C)O)C(O)=O InChI= 1S/C17H22N4O5/c1-9(22)15(21-14(23)7-18)16(24)20-13(17(25)26)6-10-8-19-12-5-3-2-4-11(10)12/h2-5,8-9,13,15,19,22H,6-7,18H2,1H3,(H,20,24)(H,21,23)(H,25,26)/t9-,13+,15+/m1/s1 InChIKey: WSWWTQYHFCBKBT-DVJZZOLTSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9165)
Evidence 2 Activity

Activity

IC50
Antihypertensive
464.60 µM
Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Chen G. W., Tsai J. S., Pan B. S.
Purification of angiotensin I-converting inhibitory peptides and antihypertensive effect of milk produced by protease-facilitate lactic fermentation. Int. Dairy J., 2007, 17, 641-647
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@@](Cc1c[nH]c2ccccc12)(NC(=O)[C@@]([H])(NC(=O)CN)[C@@H](C)O)C(O)=O InChI= 1S/C17H22N4O5/c1-9(22)15(21-14(23)7-18)16(24)20-13(17(25)26)6-10-8-19-12-5-3-2-4-11(10)12/h2-5,8-9,13,15,19,22H,6-7,18H2,1H3,(H,20,24)(H,21,23)(H,25,26)/t9-,13+,15+/m1/s1 InChIKey: WSWWTQYHFCBKBT-DVJZZOLTSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9165)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
3