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Peptide record

TPDB00666

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB00666
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 10-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GPVRGPFPII
Physicochemical Analysis
C51H81N13O11
ANDCEQHLKMSTWY
P
1052.28
11.05
1
0
4
+1
0.50
0.590
107.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
0
L
0
K
0
M
1
F
3
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 0 M: 0 F: 1 P: 3 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C51H81N13O11
1052.28
11.05
+1
0.50
0.590
1052.2661
1051.6160
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Hernandez-Ledesma B., Amigo L., Ramos M., Recio I.
Angiotensin converting enzyme inhibitory activity in commercial fermented products. Formation of peptides under simulated gastrointestinal digestion. J. Agric. Food Chem. 52, 1504–1510, 2004
2004
Journal

Other

10
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O InChI=1S/C51H81N13O11/c1-7-30(5)41(48(72)61-42(50(74)75)31(6)8-2)60-46(70)37-21-15-25-64(37)49(73)34(26-32-16-10-9-11-17-32)58-44(68)35-19-14-24-63(35)39(66)28-56-43(67)33(18-12-22-55-51(53)54)57-47(71)40(29(3)4)59-45(69)36-20-13-23-62(36)38(65)27-52/h9-11,16-17,29-31,33-37,40-42H,7-8,12-15,18-28,52H2,1-6H3,(H,56,67)(H,57,71)(H,58,68)(H,59,69)(H,60,70)(H,61,72)(H,74,75)(H4,53,54,55)/t30-,31-,33-,34-,35-,36-,37-,40-,41-,42-/m0/s1 InChIKey=UMQRNERFPHYGAM-SNDBGJAESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8286) the DFBP database
Evidence 2 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Hernandez-Ledesma B., Amigo L., Ramos M., Recio I.
Angiotensin converting enzyme inhibitory activity in commercial fermented products. Formation of peptides under simulated gastrointestinal digestion. J. Agric. Food Chem. 52, 1504–1510, 2004
2004
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
10
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])(CCCNC(=N)N)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O InChI=1S/C51H81N13O11/c1-7-30(5)41(48(72)61-42(50(74)75)31(6)8-2)60-46(70)37-21-15-25-64(37)49(73)34(26-32-16-10-9-11-17-32)58-44(68)35-19-14-24-63(35)39(66)28-56-43(67)33(18-12-22-55-51(53)54)57-47(71)40(29(3)4)59-45(69)36-20-13-23-62(36)38(65)27-52/h9-11,16-17,29-31,33-37,40-42H,7-8,12-15,18-28,52H2,1-6H3,(H,56,67)(H,57,71)(H,58,68)(H,59,69)(H,60,70)(H,61,72)(H,74,75)(H4,53,54,55)/t30-,31-,33-,34-,35-,36-,37-,40-,41-,42-/m0/s1 InChIKey=UMQRNERFPHYGAM-SNDBGJAESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8286) the DFBP database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb FermFooDB
DFBP
Additional Detail Fields 1 fields
10