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Peptide record

TPDB00656

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB00656
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 15-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
GPLGLLGFLGPLGLS
Physicochemical Analysis
C68H111N15O17
ARNDCEQHIKMTWYV
L
1410.72
6.02
0
0
7
-0
-3.41
1.307
156.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
0
I
6
L
0
K
0
M
1
F
2
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 0 L: 6 K: 0 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C68H111N15O17
1410.72
6.02
-0
-3.41
1.307
1410.6948
1409.8256
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
90.03 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

NA
Alemán A., Giménez B., Pérez-Santin E., Gómez-Guillén M. C., Montero P.
Contribution of Leu and Hyp residues to antioxidant and ACE-inhibitory activities of peptide isolated from squid gelatin hydrolysate. Food Chem., 125, 334-341, 2011
2011
Journal

Other

15
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001. Peptide possess also antioxidative activity (BIOPEP ID 8289)
Evidence 2 Activity

Activity

IC50
Antihypertensive
90.03 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Alemán A., Giménez B., Pérez-Santin E., Gómez-Guillén M. C., Montero P.
Contribution of Leu and Hyp residues to antioxidant and ACE-inhibitory activities of peptide isolated from squid gelatin hydrolysate. Food Chem., 125, 334-341, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
15
Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001. Peptide possess also antioxidative activity (BIOPEP ID 8289)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
15