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Peptide record

TPDB00634

ACE inhibitor C1 mother ACE inhibitors Anticancer Antioxidant standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB00634
ACE inhibitor C1 mother
ACE inhibitors Anticancer Antioxidant
Cardiometabolic peptides Cancer-related peptides Functional / health-promoting peptides
Peptipedia CancerPPD 2.0 dbACP AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Anticancer, and Antioxidant) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
GLTSK
Physicochemical Analysis
C21H40N6O8
ARNDCEQHIMFPWYV
GLKST
504.58
10.10
1
0
1
+1
0.71
-0.400
78.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C21H40N6O8
504.58
10.10
+1
0.71
-0.400
Free
504.5761
L
Linear
504.2898
Free
Anticancer
Common bean fractions
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
65.40 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Luna-Vital D. A., Gonzalez de Mejia E., Mendoza S., Loarca-Pina G.
Peptides present in the non-digestible fraction of common beans (Phaseolus vulgaris L.) inhibit the angiotensin-I converting enzyme by interacting with its catalytic cavity independent of their antioxidant capacity. Food Funct., 6, 1470-1479, 2015
2015
Journal

Other

5
BIOPEP database of bioactive peptides SMILES: NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O InChI=1S/C21H40N6O8/c1-11(2)8-14(24-16(30)9-23)18(31)27-17(12(3)29)20(33)26-15(10-28)19(32)25-13(21(34)35)6-4-5-7-22/h11-15,17,28-29H,4-10,22-23H2,1-3H3,(H,24,30)(H,25,32)(H,26,33)(H,27,31)(H,34,35)/t12-,13+,14+,15+,17+/m1/s1 InChIKey: NURUXHWYSWXTSX-MDLJMBGESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9098)
Evidence 2 Activity

Activity

50.11 ± 2.09 inhibition % at 10 µM
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

78.7 ± 1.60 inhibition % at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019
Evidence 4 Activity

Activity

93.01 ± 1.01 inhibition % at 10 µM
Anticancer

Target

Colon Cancer
HT-29
Colon

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019
Evidence 5 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
5