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Peptide record

TPDB00629

Antibacterial Anticancer Antifungal Antioxidant Toxicity standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB00629
Antibacterial Anticancer Antifungal Antioxidant Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 Peptipedia AFP-GFuse CAFPdb dbAMP AODB ToxinPred 3.0
standard
No
A 28-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GLISTIWNTASNVAGTLTDSVKCKFKKC
Physicochemical Analysis
C131H217N35O40S2
REQHMPY
KT
2986.49
9.72
4
1
10
+3
1.60
0.121
83.57
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
188.35
11
Residue Composition
number
2
A
0
R
2
N
1
D
2
C
0
E
0
Q
2
G
0
H
2
I
2
L
4
K
0
M
1
F
0
P
3
S
4
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 2 D: 1 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 4 M: 0 F: 1 P: 0 S: 3 T: 4 W: 1 Y: 0 V: 2
Chemical Descriptors
28
C131H217N35O40S2
2986.49
9.72
+3
1.60
0.121
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against the fungus C. albicans. Ranatuerin-2SSa was slightly active against plant pathogen C. michiganensis subsp. michiganensis. Moderate antioxidant activity (20 ug/mL at 21.9%).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against the fungus C. albicans. Ranatuerin-2SSa was slightly active against plant pathogen C. michiganensis subsp. michiganensis. Moderate antioxidant activity (20 ug/mL at 21.9%).
Evidence 3 Activity

Activity

61.7% Killing
Toxicity
32 µg/mL
Cytotoxic
61.7% Killing | 32 | µg/mL | target cell: Monkey COS-7 cells

Target

Monkey COS-7 cells

Source & Reference

NA
DBAASP
Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens. | Antibiotics (Basel) | 2020
Evidence 4 Activity

Activity

67.1% Killing
Toxicity
32 µg/mL
Cytotoxic
67.1% Killing | 32 | µg/mL | target cell: Calf pulmonary artery endothelium (CPAE)

Target

Calf pulmonary artery endothelium (CPAE)

Source & Reference

NA
DBAASP
Antimicrobial Property and Mode of Action of the Skin Peptides of the Sado Wrinkled Frog, Glandirana susurra, against Animal and Plant Pathogens. | Antibiotics (Basel) | 2020
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: COS-7: 88.5% Killing=32µg/ml CPAE: 99.2% Killing=32µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2020 Jul 29 9(8):457.