Back to search

Peptide record

TPDB00628

Esculentin-1GN Anti-inflammatory Antibacterial Anticancer Antifungal Antioxidant Antiviral Toxicity standard
49 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB00628
Esculentin-1GN
Anti-inflammatory Antibacterial Anticancer Antifungal Antioxidant Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides Functional / health-promoting peptides
Peptipedia AntiBP3 AFP-GFuse Antifungipept CAFPdb dbAMP AODB DRAVP 2.0 DBAASP
standard
No
A 49-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
GLFSKKGGKGGKSWIKGVFKGIKGIGKEVGGDVIRTGIEIAACKIKGEC
Physicochemical Analysis
C225H379N63O61S2
NQHMPY
G
5006.99
10.36
11
4
16
+7
11.08
-0.078
85.51
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5625
112.34
5
Residue Composition
number
2
A
1
R
0
N
1
D
2
C
3
E
0
Q
13
G
0
H
7
I
1
L
10
K
0
M
2
F
0
P
2
S
1
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 2 E: 3 Q: 0 G: 13 H: 0 I: 7 L: 1 K: 10 M: 0 F: 2 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 3
Chemical Descriptors
49
C225H379N63O61S2
5006.99
10.36
+7
11.08
-0.078
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.7 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
1.9-40 µM

Target

Staphylococcus aureus ATCC 25923 or ampicillin and benzylpencillin-resistant

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM)
Evidence 4 Activity

Activity

MIC
Antibacterial
1.17 µM

Target

P. acnes

Source & Reference

dbAMP

Other

, Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25
Evidence 5 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

S. subtilis ATCC 6633

Source & Reference

dbAMP

Other

5923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25922 in 180 min at 2 or 4xMIC.
Evidence 6 Activity

Activity

MIC
Antibacterial
4.7 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

esistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25922 in 180 min at 2 or 4xMIC.
Evidence 7 Activity

Activity

MIC
Antifungal
3.7 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-
Evidence 8 Activity

Activity

MIC
Antifungal
50 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
1.9-40 µM

Target

Staphylococcus aureus ATCC 25923 or ampicillin and benzylpencillin-resistant

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM)
Evidence 10 Activity

Activity

MIC
Antifungal
1.17 µM

Target

P. acnes

Source & Reference

dbAMP CAFPdb Antifungipept

Other

, Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25
Evidence 11 Activity

Activity

MIC
Antifungal
3.1 µM

Target

S. subtilis ATCC 6633

Source & Reference

dbAMP CAFPdb Antifungipept

Other

5923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25922 in 180 min at 2 or 4xMIC.
Evidence 12 Activity

Activity

MIC
Antifungal
4.7 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

esistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25922 in 180 min at 2 or 4xMIC.
Evidence 13 Activity

Activity

MIC
Antiviral
3.7 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAVP 2.0

Other

Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-
Evidence 14 Activity

Activity

MIC
Antiviral
50 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAVP 2.0

Other

Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM),
Evidence 15 Activity

Activity

MIC
Antiviral
1.9-40 µM

Target

Staphylococcus aureus ATCC 25923 or ampicillin and benzylpencillin-resistant

Source & Reference

DRAVP 2.0

Other

Active against E. coli ATCC 25922 (MIC 3.7 uM), P. aeruginosa (MIC 50 uM), Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM)
Evidence 16 Activity

Activity

MIC
Antiviral
1.17 µM

Target

P. acnes

Source & Reference

DRAVP 2.0

Other

, Gram+ S. aureus ATCC 25923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25
Evidence 17 Activity

Activity

MIC
Antiviral
3.1 µM

Target

S. subtilis ATCC 6633

Source & Reference

DRAVP 2.0

Other

5923 or ampicillin and benzylpencillin-resistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25922 in 180 min at 2 or 4xMIC.
Evidence 18 Activity

Activity

MIC
Antiviral
4.7 µM

Target

Candida albicans

Source & Reference

DRAVP 2.0

Other

esistant (MIC 1.9-40 uM), P. acnes (MIC 1.17 uM), S. subtilis ATCC 6633 (MIC 3.1 uM), and C. albicans (MIC 4.7 uM). Killed E. coli ATCC 25922 in 180 min at 2 or 4xMIC.
Evidence 19 Activity

Activity

IC50
Toxicity
43.82±1.82 µM
Cytotoxic
IC50 | 43.82±1.82 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo. | J Med Chem | 2018
Evidence 20 Activity

Activity

IC50
Toxicity
26.08±2.45 µM
Cytotoxic
IC50 | 26.08±2.45 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo. | J Med Chem | 2018
Evidence 21 Activity

Activity

50% Hemolysis
Toxicity
>40 µM
Hemolytic Cytotoxic
50% Hemolysis | >40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Functional Characterization of a Novel Lipopolysaccharide-Binding Antimicrobial and Anti-Inflammatory Peptide in Vitro and in Vivo. | J Med Chem | 2018
Evidence 22 Activity

Activity

50% Cytotoxicity
Toxicity
26.01±2.45 µM
Cytotoxic
50% Cytotoxicity | 26.01±2.45 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
Antiviral activity and mechanism of ESC-1GN from skin secretion of Hylarana guentheri against influenza A virus | J Biochem | 2021
Evidence 23 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2018 Dec 13 61(23):10709-10723.
Evidence 24 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP