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Peptide record

TPDB00627

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant iDPPIV standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB00627
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant iDPPIV
Cardiometabolic peptides Functional / health-promoting peptides
pep-lab Peptipedia AHTPDB AHTpin AODB Multi-AOP iDPPIV
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
GLDIQK
Physicochemical Analysis
C29H52N8O10
ARNCEHMFPSTWYV
DQGILK
672.78
6.75
1
1
2
-0
1.94
-0.500
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
1
Q
1
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C29H52N8O10
672.78
6.75
-0
1.94
-0.500
672.7687
672.3794
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
580.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331 (1998)
1998
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CC(C)C)NC(=O)CN)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C29H52N8O10/c1-5-16(4)24(28(45)34-17(9-10-21(32)38)25(42)35-18(29(46)47)8-6-7-11-30)37-27(44)20(13-23(40)41)36-26(43)19(12-15(2)3)33-22(39)14-31/h15-20,24H,5-14,30-31H2,1-4H3,(H2,32,38)(H,33,39)(H,34,45)(H,35,42)(H,36,43)(H,37,44)(H,40,41)(H,46,47)/t16-,17-,18-,19-,20-,24-/m0/s1 InChIKey=MWFDECNXUFBANR-KCKIOEHISA-N
Evidence 2 Activity

Activity

IC50
Antihypertensive
580.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Pihlanto-Leppala A., Rokka T., Korhonen H.
Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. Int. Dairy Journal 8, 325-331 (1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
6
BIOPEP-UWM database of bioactive peptides SMILES: [H][C@](C)(CC)[C@]([H])(NC(=O)[C@]([H])(CC(O)=O)NC(=O)[C@]([H])(CC(C)C)NC(=O)CN)C(=O)N[C@@]([H])(CCC(N)=O)C(=O)N[C@@]([H])(CCCCN)C(O)=O InChI=1S/C29H52N8O10/c1-5-16(4)24(28(45)34-17(9-10-21(32)38)25(42)35-18(29(46)47)8-6-7-11-30)37-27(44)20(13-23(40)41)36-26(43)19(12-15(2)3)33-22(39)14-31/h15-20,24H,5-14,30-31H2,1-4H3,(H2,32,38)(H,33,39)(H,34,45)(H,35,42)(H,36,43)(H,37,44)(H,40,41)(H,46,47)/t16-,17-,18-,19-,20-,24-/m0/s1 InChIKey=MWFDECNXUFBANR-KCKIOEHISA-N
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB
DFBP
Additional Detail Fields 1 fields
6