TPDB

3D PDB MODEL

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TPDB ID TPDB00619

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb

Sequence_Type

standard

Has_Modification No

Description A 7-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, and AoXpDb, with an available 3D structural model.

Sequence

GKDAVIV

FASTA

>TPDB00619|ACE inhibitors;Antioxidant|length=7
GKDAVIV

Formula C31H56N8O10

Absent Amino Acids RNCEQHLMFPSTWY

Common Amino Acids V

Mass 700.83

PI 6.75

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 4

Net Charge -0

Boman Index 1.89

Hydrophobicity 0.986

Aliphatic Index 152.86

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

1

A

0

R

0

N

1

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

1

K

0

M

0

F

0

P

0

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2

Length

7

Formula

C31H56N8O10

Mass

700.83

PI

6.75

Net Charge

-0

Boman Index

1.89

Hydrophobicity

0.986

Chemical_Mass

700.8217

Monoisotopic_Mass

700.4106

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 18.30 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 7

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CCCCN)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(C(C)C)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C(C)C)C(=O)O InChI=1S/C31H56N8O10/c1-8-17(6)25(30(47)38-24(16(4)5)31(48)49)39-29(46)23(15(2)3)37-26(43)18(7)34-28(45)20(13-22(41)42)36-27(44)19(11-9-10-12-32)35-21(40)14-33/h15-20,23-25H,8-14,32-33H2,1-7H3,(H,34,45)(H,35,40)(H,36,44)(H,37,43)(H,38,47)(H,39,46)(H,41,42)(H,48,49)/t17-,18-,19-,20-,23-,24-,25-/m0/s1 InChIKey=NRTXGGDOOQZQMA-UJRRAURJSA-N Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9838) Inhibitor of alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9839) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9444)

Number_of_Residues

7