TPDB00614

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.9 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megathe

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5 µg/mL

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 u

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.9 µg/mL

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.9 µg/mL

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

CCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 15 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

erium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). It also has anti-HIV and spermicida

Evidence 8 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=11.4 µg/ml

Detail Source Activity Anticancer

Activity Measurement 11.4 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line C8166

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Other

Source Activity Label	Source Definition
Anticancer	CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.

Evidence 9 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =25.2 µg/ml

Detail Source Activity Anticancer

Activity Measurement 25.2 µg/mL

Target

Cancer Type Leukemia Cancer

Cell Line MOLT-4

Tissue Affected Blood

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 10 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50=28 µg/ml

Detail Source Activity Anticancer

Activity Measurement 28 µg/mL

Target

Cancer Type Bladder Cancer

Cell Line BIU-87

Tissue Affected Bladder

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 11 Activity

Activity

Activity Endpoint IC50

Activity Raw

IC50 =18 µg/ml

Detail Source Activity Anticancer

Activity Measurement 18 µg/mL

Target

Cancer Type Bladder Cancer

Cell Line T-24

Tissue Affected Bladder

Assay & Model

Assay MTT/MTS assay

Testing Time 48-h

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2001

Evidence 12 Activity

Activity

Activity Raw

Not Available

Detail Source Activity Anticancer

Target

Cancer Type Not Available

Cell Line Not Available

Tissue Affected Not Available

Assay & Model

Assay Not Available

Testing Time Not Available

Source & Reference

Database Source dbAMP 3.0 CancerPPD 2.0 dbACP SATPdb

Source CancerPPD2

Year 2002

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.9 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megathe

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.5 µg/mL

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 u

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.9 µg/mL

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 0.9 µg/mL

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

CCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 15 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

erium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). It also has anti-HIV and spermicida

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.9 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megathe

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.1 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.5 µg/mL

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 u

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.9 µg/mL

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 0.9 µg/mL

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 3.1 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

CCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 15 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

erium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). It also has anti-HIV and spermicida

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.9 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megathe

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.1 µg/mL

Target

Target Organism Staphylococcus aureus ATCC2592

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1.5 µg/mL

Target

Target Organism B. pyocyaneus CMCCB10104

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

Active against E. coli ATCC25922 (MIC 0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 u

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.9 µg/mL

Target

Target Organism B. megatherium

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

0.9 ug/ml), S. aureus ATCC2592 (MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002

Evidence 31 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 0.9 µg/mL

Target

Target Organism B. dysenterium

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

MIC 3.1 ug/ml), B. pyocyaneus CMCCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (

Evidence 32 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 3.1 µg/mL

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

CCB10104 (MIC 1.5 ug/ml), B. megatherium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND

Evidence 33 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 15 µM

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP 3.0 DRAMP DRAVP 2.0

Other

Evidence Text

erium (MIC 0.9 ug/ml), B. dysenterium (MIC 0.9 ug/ml), K. pneumoniae (MIC 3.1 ug/ml), and C. albicans ATCC2002 (MIC 15 uM), A.flavus IFFI4015 (ND), and P.uticale IFFI2001 (ND). It also has anti-HIV and spermicida

Evidence 34 Activity

Activity

Activity Endpoint Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 50 µg/mL

Hemolysis Raw

[Ref:11835991]Little hemolytic activity at 50 µg/ml against red blood cells

Target

RBC Target red blood cells

Source & Reference

Database Source APD_complete APD_hemolytic

Source DRAMP4

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.

Evidence 35 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:11835991]Little hemolytic activity at 50 µg/ml against red blood cells

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.

Evidence 36 Hemolysis

Activity

Activity Measurement 50 µg/mL

Activity Endpoint Hemolysis

Hemolysis Raw

[Ref:11835991]Little hemolytic activity at 50 µg/ml against red blood cells

Detail Source Activity Hemolysis

Target

RBC Target red blood cells

Source & Reference

source APD_complete APD_hemolytic

Reference

Eur J Immunol. 2005 Apr 35(4):1220-9.##Peptides. 2002 Mar 23(3):427-435.

Source DRAMP4

Database Source APD_complete APD_hemolytic