TPDB

3D PDB MODEL

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TPDB ID TPDB00590

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

pep-lab Peptipedia AoXpDb

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from pep-lab, Peptipedia, and AoXpDb, with an available 3D structural model.

Sequence

GFPGER

FASTA

>TPDB00590|ACE inhibitors;Antioxidant|length=6
GFPGER

Formula C29H43N9O9

Absent Amino Acids ANDCQHILKMSTWYV

Common Amino Acids G

Mass 661.72

PI 6.97

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -0

Boman Index 2.17

Hydrophobicity -1.267

Aliphatic Index 0.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

1

R

0

N

0

D

0

C

1

E

0

Q

2

G

0

H

0

I

0

L

0

K

0

M

1

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C29H43N9O9

Mass

661.72

PI

6.97

Net Charge

-0

Boman Index

2.17

Hydrophobicity

-1.267

Chemical_Mass

661.7049

Monoisotopic_Mass

661.3174

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 952.60 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Dara P. K., Elavarasan K., Shamasundar B. A.

Title

Improved utilization of croaker skin waste and freshwater carps visceral waste: conversion of waste to health benefitting peptides. Int. J. Pept. Res. Therapeut., 26, 2641–2651, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides: SMILES: [H][C@@](CCCNC(N)=N)(NC(=O)[C@]([H])(CCC(O)=O)NC(=O)CNC(=O)[C@]1([H])CCCN1C(=O)[C@]([H])(CC1=CC=CC=C1)NC(=O)CN)C(O)=O InChI=1S/C29H43N9O9/c30-15-22(39)36-20(14-17-6-2-1-3-7-17)27(45)38-13-5-9-21(38)26(44)34-16-23(40)35-18(10-11-24(41)42)25(43)37-19(28(46)47)8-4-12-33-29(31)32/h1-3,6-7,18-21H,4-5,8-16,30H2,(H,34,44)(H,35,40)(H,36,39)(H,37,43)(H,41,42)(H,46,47)(H4,31,32,33)/t18-,19-,20-,21-/m0/s1 InChIKey=DNSUZJGAZZOUGK-TUFLPTIASA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID M02-001

Number_of_Residues

6