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Peptide record

TPDB00588

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB00588
Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Neurotoxin Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis NTxPred2 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFGSLFKFLAKKVAKTVAKQAAKQGAKYVANKHME
Physicochemical Analysis
C175H284N48O44S1
RDCIPW
K
3796.54
10.78
9
1
17
+7
6.12
-0.266
67.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
39.25
6
Residue Composition
number
7
A
0
R
1
N
0
D
0
C
1
E
2
Q
3
G
1
H
0
I
2
L
8
K
1
M
3
F
0
P
1
S
1
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 7 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 3 H: 1 I: 0 L: 2 K: 8 M: 1 F: 3 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 3
Chemical Descriptors
35
C175H284N48O44S1
3796.54
10.78
+7
6.12
-0.266
Evidence Records 5 records
Evidence 1 Activity

Activity

Hemolysis
[Ref.11792701]Not determined

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
J Biol Chem. 2002 Mar 29 277(13):11208-11216.##Toxicon. 2000 Mar 38(3):373-380.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

Neurotoxin
FUNCTION: Has antimicrobial activity against B.subtilis, E.coli, E.faecalis, P.aeruginosa, and S.aureus. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane function with its amphipathic structure. {ECO:0000269|PubMed:10669026, ECO:0000269|PubMed:11792701, ECO:0000303|PubMed:11792701}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cupiennius salei (American wandering spider)
Neurotoxin
Has antimicrobial activity against B.subtilis, E.coli, E.faecalis, P.aeruginosa, and S.aureus. Has insecticidal and hemolytic activities.
Cupiennin-1d (Cu-1d) (M-ctenitoxin-Cs1d) (M-CNTX-Cs1d)
spider
Cationic peptide 04 (cupiennin) family, 01 subfamily
Evidence at protein level
Amidation Antibiotic Antimicrobial Cytolysis Direct protein sequencing Hemolysis Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
14.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 14.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11792701]Not determined

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2002 Mar 29 277(13):11208-11216.##Toxicon. 2000 Mar 38(3):373-380.
Evidence 5 Hemolysis

Activity

[Ref.11792701]Not determined
Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
J Biol Chem. 2002 Mar 29 277(13):11208-11216.##Toxicon. 2000 Mar 38(3):373-380.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.
Additional Detail Fields 7 fields
Amidation Antibiotic Antimicrobial Cytolysis Direct protein sequencing Hemolysis Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Cationic peptide 04 (cupiennin) family, 01 subfamily
Cupiennin-1d (Cu-1d) (M-ctenitoxin-Cs1d) (M-CNTX-Cs1d)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider