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Peptide record

TPDB00587

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Neurotoxin Toxicity standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB00587
Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Neurotoxin Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept NTxPred2 ToxinPred 3.0
standard
No
A 35-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFGSLFKFLAKKVAKTVAKQAAKQGAKYIANKQME
Physicochemical Analysis
C175H287N47O45S1
RDCHPW
K
3801.55
10.78
8
1
17
+7
5.36
-0.266
70.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
39.19
7
Residue Composition
number
7
A
0
R
1
N
0
D
0
C
1
E
3
Q
3
G
0
H
1
I
2
L
8
K
1
M
3
F
0
P
1
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 7 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 3 G: 3 H: 0 I: 1 L: 2 K: 8 M: 1 F: 3 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
35
C175H287N47O45S1
3801.55
10.78
+7
5.36
-0.266
Evidence Records 2 records
Evidence 1 Activity

Activity

Neurotoxin
FUNCTION: Has antimicrobial activity against E.coli, E.faecalis, P.aeruginosa, and S.aureus. Has insecticidal and hemolytic activities. Probably acts by disturbing membrane function with its amphipathic structure. {ECO:0000269|PubMed:11792701, ECO:0000303|PubMed:11792701}.

Source & Reference

NA
UniProtKB/Swiss-Prot Tox-Prot

Other

Cupiennius salei (American wandering spider)
Neurotoxin
Has antimicrobial activity against E.coli, E.faecalis, P.aeruginosa, and S.aureus. Has insecticidal and hemolytic activities.
Cupiennin-1b (Cu-1b) (M-ctenitoxin-Cs1b) (M-CNTX-Cs1b)
spider
Cationic peptide 04 (cupiennin) family, 01 subfamily
Evidence at protein level
Amidation Antibiotic Antimicrobial Cytolysis Direct protein sequencing Hemolysis Neurotoxin Secreted Toxin
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11792701]Not determined

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2002 Mar 29 277(13):11208-11216.
Additional Detail Fields 7 fields
Amidation Antibiotic Antimicrobial Cytolysis Direct protein sequencing Hemolysis Neurotoxin Secreted Toxin
Neurotoxin
Evidence at protein level
Cationic peptide 04 (cupiennin) family, 01 subfamily
Cupiennin-1b (Cu-1b) (M-ctenitoxin-Cs1b) (M-CNTX-Cs1b)
TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
spider