Back to search

Peptide record

TPDB00582

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity standard
69 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB00582
Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
dbAMP DRAMP Peptipedia Antifungipept APD_complete HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 69-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from dbAMP, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKYYGKKALQKASEKL
Physicochemical Analysis
C363H612N96O93S3
CHP
K
7905.62
10.62
20
6
30
+14
19.39
-0.604
84.93
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
9970
126.11
11
Residue Composition
number
7
A
1
R
1
N
2
D
0
C
4
E
3
Q
5
G
0
H
5
I
6
L
19
K
3
M
2
F
0
P
3
S
1
T
1
W
3
Y
3
V
Amino Acid Distribution
A: 7 R: 1 N: 1 D: 2 C: 0 E: 4 Q: 3 G: 5 H: 0 I: 5 L: 6 K: 19 M: 3 F: 2 P: 0 S: 3 T: 1 W: 1 Y: 3 V: 3
Chemical Descriptors
69
C363H612N96O93S3
7905.62
10.62
+14
19.39
-0.604
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-0.9 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram-positive bacteria A. globiformis, B. subtilis (MIC 0.5-0.9 uM) and Gram-negative bacteria E. coli and P. aeruginosa (MIC 0.5-1.9 uM). The peptide is hel
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5-1.9 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

teria A. globiformis, B. subtilis (MIC 0.5-0.9 uM) and Gram-negative bacteria E. coli and P. aeruginosa (MIC 0.5-1.9 uM). The peptide is helical in TFE, SDS, or DOPC LUVs. Recently, it was shown to inhibit C. t
Evidence 3 Activity

Activity

MIC
Antifungal
0.5-0.9 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram-positive bacteria A. globiformis, B. subtilis (MIC 0.5-0.9 uM) and Gram-negative bacteria E. coli and P. aeruginosa (MIC 0.5-1.9 uM). The peptide is hel
Evidence 4 Activity

Activity

MIC
Antifungal
0.5-1.9 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

teria A. globiformis, B. subtilis (MIC 0.5-0.9 uM) and Gram-negative bacteria E. coli and P. aeruginosa (MIC 0.5-1.9 uM). The peptide is helical in TFE, SDS, or DOPC LUVs. Recently, it was shown to inhibit C. t
Evidence 5 Activity

Activity

MIC
Antiparasitic
0.5-0.9 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram-positive bacteria A. globiformis, B. subtilis (MIC 0.5-0.9 uM) and Gram-negative bacteria E. coli and P. aeruginosa (MIC 0.5-1.9 uM). The peptide is hel
Evidence 6 Activity

Activity

MIC
Antiparasitic
0.5-1.9 µM

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

teria A. globiformis, B. subtilis (MIC 0.5-0.9 uM) and Gram-negative bacteria E. coli and P. aeruginosa (MIC 0.5-1.9 uM). The peptide is helical in TFE, SDS, or DOPC LUVs. Recently, it was shown to inhibit C. t
Evidence 7 Activity

Activity

EC50
Hemolysis
6 µM
[Ref.18215128]EC50=6 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Biochem J. 2008 May 1 411(3):687-696.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
6 µM
Hemolytic Cytotoxic
50% Hemolysis | 6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom | Biochem J | 2008
Evidence 9 Activity

Activity

EC50
Toxicity
6 µM
Hemolytic
Hemolytic_activity: [Ref.18215128]EC50=6 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem J. 2008 May 1 411(3):687-696.
Evidence 10 Hemolysis

Activity

6 µM
EC50
[Ref.18215128]EC50=6 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete HemoPI PD_Hemolysis
Biochem J. 2008 May 1 411(3):687-696.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.