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Peptide record

TPDB00575

Antioxidative peptide P1 Antioxidant standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB00575
Antioxidative peptide P1
Antioxidant
Functional / health-promoting peptides
AODB Multi-AOP
standard
No
A 16-aa standard natural antioxidant peptide sequence curated from AODB and Multi-AOP, with an available 3D structural model.
Sequence
GEPGPPGPPGPPGPPG
Physicochemical Analysis
C62H90N16O19
ARNDCQHILKMFSTWYV
P
1363.49
3.29
0
1
0
-1
6.13
-1.269
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
6
G
0
H
0
I
0
L
0
K
0
M
0
F
9
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 6 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 9 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C62H90N16O19
1363.49
3.29
-1
6.13
-1.269
3.34
0.00
NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)N1[C@@]([H])(CCC1)C(=O)N1[C@@]([H])(CCC1)C(=O)NCC(=O)O
1363.49 Da
Evidence Records 1 records
Evidence 1 Activity

Activity

Antioxidative activity
(1) The bioactive sequence of the peptide is Gly-Glu-Hyp-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly-Pro-Hyp-Gly. Hydroxyproline (Hyp) is a product of hydroxylation of proline. (2) The antioxidative activity of the purified peptide in a water/alcohol system was examined by the TBA method and the peptide showed potent antioxidative activity (MDA concentartion, about 2.63 × 10^-7 M).
Literature report: N.D Prediction: ToxinPred
Antioxidant

Assay & Model

Enzymatic hydrolysis
Hydrolyzed with serial digestions in the order of Alcalase, Pronase E, and collagenase using a three-step recycling membrane reactor. The fraction from the second step, which was hydrolyzed with Pronase E, showed potent antioxidative activity.

Source & Reference

AODB
Kim SK, Kim YT, Byun HG, Nam KS, Joo DS, Shahidi F. Isolation and characterization of antioxidative peptides from gelatin hydrolysate of Alaska pollack skin. J Agric Food Chem. 2001 Apr 49(4):1984-9.
10.1021/jf000494j
[1] Kim, S.K., et al., Purification and characterization of antioxidative peptides from bovine skin. Journal of Biochemistry and Molecular Biology, 2001. 34 (3): p. 219-224.
2001
DFBP

Other

Native peptide
Animal, Marine, Fish
Alaska Pollack
Gelatin extracted from Alaska Pollack Skin