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Peptide record

TPDB00573

ACE inhibitor C2 mother ACE inhibitors Anticancer Antioxidant standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB00573
ACE inhibitor C2 mother
ACE inhibitors Anticancer Antioxidant
Cardiometabolic peptides Cancer-related peptides Functional / health-promoting peptides
Peptipedia CancerPPD 2.0 dbACP AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 6-aa standard natural multi-activity (ACE inhibitors, Anticancer, and Antioxidant) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
GEGSGA
Physicochemical Analysis
C17H28N6O10
RNDCQHILKMFPTWYV
G
476.44
3.29
0
1
1
-1
2.01
-0.617
16.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C17H28N6O10
476.44
3.29
-1
2.01
-0.617
Free
476.4373
L
Linear
476.1860
Free
Anticancer
Common bean fractions
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
113.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Luna-Vital D. A., Gonzalez de Mejia E., Mendoza S., Loarca-Pina G.
Peptides present in the non-digestible fraction of common beans (Phaseolus vulgaris L.) inhibit the angiotensin-I converting enzyme by interacting with its catalytic cavity independent of their antioxidant capacity. Food Funct., 6, 1470-1479, 2015
2015
Journal

Other

6
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@@]([H])(CCC(=O)O)C(=O)NCC(=O)N[C@@]([H])(CO)C(=O)NCC(=O)N[C@@]([H])(C)C(=O)O InChI=1S/C17H28N6O10/c1-8(17(32)33)21-12(26)5-20-16(31)10(7-24)23-13(27)6-19-15(30)9(2-3-14(28)29)22-11(25)4-18/h8-10,24H,2-7,18H2,1H3,(H,19,30)(H,20,31)(H,21,26)(H,22,25)(H,23,27)(H,28,29)(H,32,33)/t8-,9-,10-/m0/s1 InChIKey: UVITXXKRQQSNPB-GUBZILKMSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9104)
Evidence 2 Activity

Activity

83.39 ± 0.84 inhibition % at 10 µM
Anticancer

Target

Breast Cancer
MCF-7
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 3 Activity

Activity

79.32 ± 0.23 inhibition % at 10 µM
Anticancer

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019
Evidence 4 Activity

Activity

92.79 ± 0.54 inhibition % at 10 µM
Anticancer

Target

Colon Cancer
HT-29
Colon

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2019
Evidence 5 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
6