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Peptide record

TPDB00560

Antibacterial Antifungal Antioxidant Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB00560
Antibacterial Antifungal Antioxidant Toxicity
Anti-infective peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP AODB Multi-AOP ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antifungal, Antioxidant, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GAPKGCWTKSYPPQPCFGKK
Physicochemical Analysis
C100H150N26O25S2
RNDEHILMV
KP
2180.57
9.98
4
0
4
+4
2.07
-1.040
5.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7115
326.29
6
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
1
Q
3
G
0
H
0
I
0
L
4
K
0
M
1
F
4
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 4 M: 0 F: 1 P: 4 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
20
C100H150N26O25S2
2180.57
9.98
+4
2.07
-1.040
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
18.8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 18.8 uM), E.faecalis 981 (inactive), N.asteroides 201118 (MIC 150 uM), P.aeruginosa CGMCC 1.50, K.
Evidence 2 Activity

Activity

MIC
Antibacterial
150 µM

Target

N.asteroides 201118

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 18.8 uM), E.faecalis 981 (inactive), N.asteroides 201118 (MIC 150 uM), P.aeruginosa CGMCC 1.50, K.pneumoniae 08040724 (inactive), E.coli ATCC 25922 (inactive),
Evidence 3 Activity

Activity

MIC
Antibacterial
150 µM

Target

C.glabrata 090902

Source & Reference

dbAMP

Other

.pneumoniae 08040724 (inactive), E.coli ATCC 25922 (inactive), C.albicans ATCC 10231, and C.glabrata 090902 (MIC 150 uM). Weak antioxidant activity. Updated 5/2019 7/2021
Evidence 4 Activity

Activity

MIC
Antifungal
18.8 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 18.8 uM), E.faecalis 981 (inactive), N.asteroides 201118 (MIC 150 uM), P.aeruginosa CGMCC 1.50, K.
Evidence 5 Activity

Activity

MIC
Antifungal
150 µM

Target

N.asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 18.8 uM), E.faecalis 981 (inactive), N.asteroides 201118 (MIC 150 uM), P.aeruginosa CGMCC 1.50, K.pneumoniae 08040724 (inactive), E.coli ATCC 25922 (inactive),
Evidence 6 Activity

Activity

MIC
Antifungal
150 µM

Target

C.glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

.pneumoniae 08040724 (inactive), E.coli ATCC 25922 (inactive), C.albicans ATCC 10231, and C.glabrata 090902 (MIC 150 uM). Weak antioxidant activity. Updated 5/2019 7/2021
Evidence 7 Activity

Activity

8.5% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
8.5% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 8 Activity

Activity

6.8% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
6.8% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017
Evidence 9 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional analyses of novel antioxidant peptides and antimicrobial peptides from skin secretions of four East Asian frog species. | Acta Biochim Biophys Sin | 2017