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Peptide record

TPDB00548

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB00548
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 5-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
FYPEL
Physicochemical Analysis
C34H45N5O9
ARNDCQGHIKMSTWV
ELFPY
667.76
3.29
0
1
3
-1
-0.16
0.040
78.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
223.13
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C34H45N5O9
667.76
3.29
-1
-0.16
0.040
667.7474
667.3206
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
81.62 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Contreras M. M., Sánchez-Infantes D., Sevilla M. A., Recio I., Amigo L.
Resistance of casein-derived bioactive peptides to simulated gastrointestinal digestión. Int. Dairy J., 32, 71–78, 2013
2013
Journal

Other

5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C34H45N5O9/c1-20(2)17-27(34(47)48)38-31(44)25(14-15-29(41)42)36-32(45)28-9-6-16-39(28)33(46)26(19-22-10-12-23(40)13-11-22)37-30(43)24(35)18-21-7-4-3-5-8-21/h3-5,7-8,10-13,20,24-28,40H,6,9,14-19,35H2,1-2H3,(H,36,45)(H,37,43)(H,38,44)(H,41,42)(H,47,48)/t24-,25-,26-,27-,28-/m0/s1 InChIKey=SNAOQMOLGPCGFY-XLIKFSOKSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8141) the EROP-Moscow database the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
81.62 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Contreras M. M., Sánchez-Infantes D., Sevilla M. A., Recio I., Amigo L.
Resistance of casein-derived bioactive peptides to simulated gastrointestinal digestión. Int. Dairy J., 32, 71–78, 2013
2013
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
5
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C34H45N5O9/c1-20(2)17-27(34(47)48)38-31(44)25(14-15-29(41)42)36-32(45)28-9-6-16-39(28)33(46)26(19-22-10-12-23(40)13-11-22)37-30(43)24(35)18-21-7-4-3-5-8-21/h3-5,7-8,10-13,20,24-28,40H,6,9,14-19,35H2,1-2H3,(H,36,45)(H,37,43)(H,38,44)(H,41,42)(H,47,48)/t24-,25-,26-,27-,28-/m0/s1 InChIKey=SNAOQMOLGPCGFY-XLIKFSOKSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8141) the EROP-Moscow database the MBPDB database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
5