TPDB

3D PDB MODEL

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TPDB ID TPDB00520

Activity

Antibacterial Antifungal Antioxidant

Activity_category_statistics

Anti-infective peptides Functional / health-promoting peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb AnOxPePred - 1.0 AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Antifungal, and Antioxidant) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FRSGILKLASKIPSVLCAVLKNC

FASTA

>TPDB00520|Antibacterial;Antifungal;Antioxidant|length=23
FRSGILKLASKIPSVLCAVLKNC

Formula C111H194N30O28S2

Absent Amino Acids DEQHMTWY

Common Amino Acids L

Mass 2461.07

PI 10.32

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +4

Boman Index 0.38

Hydrophobicity 0.865

Aliphatic Index 135.65

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.08

Polar Residues 6

number

2

A

1

R

1

N

0

D

2

C

0

E

0

Q

1

G

0

H

2

I

4

L

3

K

0

M

1

F

1

P

3

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 2 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 4 K: 3 M: 0 F: 1 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 2

Length

23

Formula

C111H194N30O28S2

Mass

2461.07

PI

10.32

Net Charge

+4

Boman Index

0.38

Hydrophobicity

0.865

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 50 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

22 (MIC 50 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Updated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 50 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

22 (MIC 50 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Updated 7/2021