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Peptide record

TPDB00517

Antihypertensive peptide derived from egg ovoalbumin ACE inhibitors Antihypertensive Antioxidant Neuropeptide standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB00517
Antihypertensive peptide derived from egg ovoalbumin
ACE inhibitors Antihypertensive Antioxidant Neuropeptide
Cardiometabolic peptides Neuroactive peptides Functional / health-promoting peptides
pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from pep-lab, Peptipedia, AHTPDB, and other sources, with an available 3D structural model.
Sequence
FRADHPFL
Physicochemical Analysis
C48H67N13O11
NCEQGIKMSTWYV
F
1002.14
7.85
2
1
4
+0
0.46
-0.200
61.25
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
1
R
0
N
1
D
0
C
0
E
0
Q
0
G
1
H
0
I
1
L
0
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C48H67N13O11
1002.14
7.85
+0
0.46
-0.200
1002.1234
1001.5068
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
Antihypertensive
0.00 µM
Lowering blood pressure in vivo in rats
hypotensive
hyp

Source & Reference

AHTPDB
Fujita H., Sasaki R., Yoshikawa M.
Potentiation of the antihypertensive activity of orally administered ovokinin, a vasorelaxing peptide derived from ovalbumin, by
1995
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=C[N]([H])C=N2)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C48H67N13O11/c1-27(2)20-37(47(71)72)60-43(67)34(22-30-14-8-5-9-15-30)58-45(69)38-17-11-19-61(38)46(70)36(23-31-25-52-26-54-31)59-44(68)35(24-39(62)63)57-40(64)28(3)55-42(66)33(16-10-18-53-48(50)51)56-41(65)32(49)21-29-12-6-4-7-13-29/h4-9,12-15,25-28,32-38H,10-11,16-24,49H2,1-3H3,(H,52,54)(H,55,66)(H,56,65)(H,57,64)(H,58,69)(H,59,68)(H,60,67)(H,62,63)(H,71,72)(H4,50,51,53)/t28-,32-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey=HBDDSFYGZBZVQM-KOOVRBLHSA-N
Evidence 2 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
8