TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB00498

Activity

Antibacterial Antifungal Antioxidant

Activity_category_statistics

Anti-infective peptides Functional / health-promoting peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb AODB

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Antifungal, and Antioxidant) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLSGILKLAFKIPSVLCAVLKNC

FASTA

>TPDB00498|Antibacterial;Antifungal;Antioxidant|length=23
FLSGILKLAFKIPSVLCAVLKNC

Formula C117H197N27O27S2

Absent Amino Acids RDEQHMTWY

Common Amino Acids L

Mass 2478.14

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 13

Net Charge +3

Boman Index -2.25

Hydrophobicity 1.383

Aliphatic Index 152.61

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 5.04

Polar Residues 5

number

2

A

0

R

1

N

0

D

2

C

0

E

0

Q

1

G

0

H

2

I

5

L

3

K

0

M

2

F

1

P

2

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 5 K: 3 M: 0 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 2

Length

23

Formula

C117H197N27O27S2

Mass

2478.14

PI

9.80

Net Charge

+3

Boman Index

-2.25

Hydrophobicity

1.383

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 25 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

22 (MIC 25 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Also antioxidant. Updated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC25922 (MIC 25 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

22 (MIC 25 ug/ml), S. aureus ATCC2592 (12.5 ug/ml), B. subtilis ATCC 6633 (50 ug/ml), and C. albicans ATCC2002 (MIC 25 ug/ml). Also antioxidant. Updated 7/2021