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Peptide record

TPDB00494

Antibacterial Antifungal Antioxidant Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB00494
Antibacterial Antifungal Antioxidant Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP AODB APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Antioxidant, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLPMLAGLAANFLPKIICKITKKC
Physicochemical Analysis
C124H209N29O27S3
RDEQHSWYV
LK
2634.38
10.17
4
0
13
+4
-1.22
0.967
126.25
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.74
4
Residue Composition
number
3
A
0
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
4
L
4
K
1
M
2
F
2
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 4 K: 4 M: 1 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C124H209N29O27S3
2634.38
10.17
+4
-1.22
0.967
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
100 µM

Target

E. faecium 091299

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMC
Evidence 3 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneum
Evidence 4 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP

Other

us ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. clo
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP

Other

3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MI
Evidence 6 Activity

Activity

MIC
Antibacterial
100 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

0 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 25 uM), and fungi C. glabrata 090902 (MIC 3.1 uM), and C. albicans(
Evidence 7 Activity

Activity

MIC
Antibacterial
25 µM

Target

P. faecalis X29

Source & Reference

dbAMP

Other

040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 25 uM), and fungi C. glabrata 090902 (MIC 3.1 uM), and C. albicans(ATCC 10231 (MIC 50 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

C. glabrata 090902

Source & Reference

dbAMP

Other

.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 25 uM), and fungi C. glabrata 090902 (MIC 3.1 uM), and C. albicans(ATCC 10231 (MIC 50 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram+ S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC
Evidence 10 Activity

Activity

MIC
Antifungal
100 µM

Target

E. faecium 091299

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMC
Evidence 11 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Enterococcus faecalis 981

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram+ S. aureus ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneum
Evidence 12 Activity

Activity

MIC
Antifungal
3.1 µM

Target

N. asteroides 201118

Source & Reference

dbAMP CAFPdb Antifungipept

Other

us ATCC 25923 (MIC 3.1 uM), E. faecium 091299 (MIC 100 uM), E. faecalis 981 (MIC 3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. clo
Evidence 13 Activity

Activity

MIC
Antifungal
100 µM

Target

Klebsiella pneumoniae 08040724

Source & Reference

dbAMP CAFPdb Antifungipept

Other

3.1 uM), N. asteroides 201118 (MIC 3.1 uM), Gram- P.aeruginosa CGMCC 1.50 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MI
Evidence 14 Activity

Activity

MIC
Antifungal
100 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

0 (MIC >100 uM), K. pneumoniae 08040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 25 uM), and fungi C. glabrata 090902 (MIC 3.1 uM), and C. albicans(
Evidence 15 Activity

Activity

MIC
Antifungal
25 µM

Target

P. faecalis X29

Source & Reference

dbAMP CAFPdb Antifungipept

Other

040724 (MIC 100 uM), E. cloacae CGMCC 1.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 25 uM), and fungi C. glabrata 090902 (MIC 3.1 uM), and C. albicans(ATCC 10231 (MIC 50 uM).
Evidence 16 Activity

Activity

MIC
Antifungal
3.1 µM

Target

C. glabrata 090902

Source & Reference

dbAMP CAFPdb Antifungipept

Other

.57 (MIC 100 uM), E. coli ATCC 25922 (MIC 100 uM), P. faecalis X29 (MIC 25 uM), and fungi C. glabrata 090902 (MIC 3.1 uM), and C. albicans(ATCC 10231 (MIC 50 uM).
Evidence 17 Activity

Activity

25% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
25% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 18 Activity

Activity

72% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
72% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 19 Activity

Activity

80% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
80% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 20 Activity

Activity

100% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
100% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification of multiple peptides with antioxidant and antimicrobial activities from skin and its secretions of Hylarana taipehensis, Amolops lifanensis, and Amolops granulosus. | Biochimie | 2014
Evidence 21 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.