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Peptide record

TPDB00490

Antibacterial Antifungal Antioxidant Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB00490
Antibacterial Antifungal Antioxidant Toxicity
Anti-infective peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP AODB Multi-AOP ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, Antioxidant, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLPFFAACAITRKC
Physicochemical Analysis
C75H114N18O16S2
NDEQGHMSWYV
AF
1587.96
9.15
2
0
8
+2
-2.86
1.171
77.14
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
7.87
3
Residue Composition
number
3
A
1
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
3
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 3 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C75H114N18O16S2
1587.96
9.15
+2
-2.86
1.171
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.68 ug/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active only against the tested Gram+ bacteria, including S. aureus ATCC25923 (MIC 4.68 ug/mL), S. aureus 090223+ (IS) and N. asteroids 090312+ (IS) (MIC 37.5 ug/mL).
Evidence 2 Activity

Activity

MIC
Antifungal
4.68 ug/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active only against the tested Gram+ bacteria, including S. aureus ATCC25923 (MIC 4.68 ug/mL), S. aureus 090223+ (IS) and N. asteroids 090312+ (IS) (MIC 37.5 ug/mL).
Evidence 3 Activity

Activity

2% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, Rana kunyuensis. | Zool Res | 2018
Evidence 4 Activity

Activity

17.9% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
17.9% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, Rana kunyuensis. | Zool Res | 2018
Evidence 5 Activity

Activity

15.4% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
15.4% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, Rana kunyuensis. | Zool Res | 2018
Evidence 6 Activity

Activity

20.8% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
20.8% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of C-terminal amidation and heptapeptide ring on the biological activities and advanced structure of amurin-9KY, a novel antimicrobial peptide identified from the brown frog, Rana kunyuensis. | Zool Res | 2018