Back to search

Peptide record

TPDB00484

ACE inhibitor from the skin secretions of the frog (Rana ridibunda) ACE inhibitors Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Antiviral Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB00484
ACE inhibitor from the skin secretions of the frog (Rana ridibunda)
ACE inhibitors Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Antiviral Toxicity
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
Peptipedia AntiBP3 dbAMP DRAMP AFP-GFuse Antifp Antifungipept AnOxPePred - 1.0 AODB AoXpDb Multi-AOP ToxinPred 3.0
standard
No
A 14-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, dbAMP, and other sources, with an available 3D structural model.
Sequence
FLKPLFNAALKLLP
Physicochemical Analysis
C80H129N17O16
RDCEQGHIMSTWYV
L
1585.01
10.60
2
0
9
+2
-2.10
0.979
153.57
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
2
K
0
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 2 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C80H129N17O16
1585.01
10.60
+2
-2.10
0.979
1584.9794
1583.9773
Evidence Records 23 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
22.19 µM
ACE inhibitor
ah

Source & Reference

NA
Mojallal-Tabatabaei Z., Asoodeh A., Asadi F., Nezafati H.R.
ACE-Inhibitory and Antioxidant Activity of Temporin-Ra Peptide: Biochemical Characterization and Molecular Modeling Study. Int. J. Pept. Res. Ther. 20, 493–500, DOI 10.1007/s10989-014-9416-x.
2014
Journal

Other

14
Reveals also antioxidative activity (BIOPEP ID 8433).
Evidence 2 Activity

Activity

MIC
Antibacterial
24.2 µg/mL

Target

Escherichia coli HP101BA 7601c

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S.
Evidence 3 Activity

Activity

MIC
Antibacterial
33.2 µg/mL

Target

S. dysgalactiae PTCC 1074

Source & Reference

dbAMP DRAMP

Other

Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. p
Evidence 4 Activity

Activity

MIC
Antibacterial
24.7 µg/mL

Target

Streptococcus agalactiae PTCC 1365

Source & Reference

dbAMP DRAMP

Other

ainst E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
35.2 µg/mL

Target

Staphylococcus aureus PTCC 1431

Source & Reference

dbAMP DRAMP

Other

l), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
31.2 µg/mL

Target

Klebsiella pneumoniae PTCC 1388

Source & Reference

dbAMP DRAMP

Other

/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
24.2 µg/mL

Target

Escherichia coli HP101BA 7601c

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S.
Evidence 8 Activity

Activity

MIC
Antifungal
33.2 µg/mL

Target

S. dysgalactiae PTCC 1074

Source & Reference

dbAMP DRAMP Antifungipept

Other

Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. p
Evidence 9 Activity

Activity

MIC
Antifungal
24.7 µg/mL

Target

Streptococcus agalactiae PTCC 1365

Source & Reference

dbAMP DRAMP Antifungipept

Other

ainst E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
35.2 µg/mL

Target

Staphylococcus aureus PTCC 1431

Source & Reference

dbAMP DRAMP Antifungipept

Other

l), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 11 Activity

Activity

MIC
Antifungal
31.2 µg/mL

Target

Klebsiella pneumoniae PTCC 1388

Source & Reference

dbAMP DRAMP Antifungipept

Other

/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 12 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Evidence 13 Activity

Activity

MIC
Antiparasitic
24.2 µg/mL

Target

Escherichia coli HP101BA 7601c

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S.
Evidence 14 Activity

Activity

MIC
Antiparasitic
33.2 µg/mL

Target

S. dysgalactiae PTCC 1074

Source & Reference

DRAMP

Other

Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. p
Evidence 15 Activity

Activity

MIC
Antiparasitic
24.7 µg/mL

Target

Streptococcus agalactiae PTCC 1365

Source & Reference

DRAMP

Other

ainst E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 16 Activity

Activity

MIC
Antiparasitic
35.2 µg/mL

Target

Staphylococcus aureus PTCC 1431

Source & Reference

DRAMP

Other

l), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 17 Activity

Activity

MIC
Antiparasitic
31.2 µg/mL

Target

Klebsiella pneumoniae PTCC 1388

Source & Reference

DRAMP

Other

/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 18 Activity

Activity

MIC
Antiviral
24.2 µg/mL

Target

Escherichia coli HP101BA 7601c

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S.
Evidence 19 Activity

Activity

MIC
Antiviral
33.2 µg/mL

Target

S. dysgalactiae PTCC 1074

Source & Reference

DRAMP

Other

Active against E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. p
Evidence 20 Activity

Activity

MIC
Antiviral
24.7 µg/mL

Target

Streptococcus agalactiae PTCC 1365

Source & Reference

DRAMP

Other

ainst E. coli HP101BA 7601c (MIC 24.2 ug/ml), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 21 Activity

Activity

MIC
Antiviral
35.2 µg/mL

Target

Staphylococcus aureus PTCC 1431

Source & Reference

DRAMP

Other

l), S. dysgalactiae PTCC 1074 (MIC 33.2 ug/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 22 Activity

Activity

MIC
Antiviral
31.2 µg/mL

Target

Klebsiella pneumoniae PTCC 1388

Source & Reference

DRAMP

Other

/ml), S. agalactiae PTCC 1365 (MIC 24.7 ug/ml), S. aureus PTCC 1431 (MIC 35.2 ug/ml), and K. pneumoniae PTCC 1388 (MIC 31.2 ug/ml).
Evidence 23 Activity

Activity

1% Hemolysis
Toxicity
60 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 60 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda). | J Pept Sci | 2012
Additional Detail Fields 1 fields
14