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Peptide record

TPDB00479

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB00479
Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLFSLIPSAISGLISAFK
Physicochemical Analysis
C94H147N19O23
RNDCEQHMTWYV
S
1911.31
10.10
1
0
11
+1
-4.37
1.544
141.11
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
4
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
3
L
1
K
0
M
3
F
1
P
4
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 1 M: 0 F: 3 P: 1 S: 4 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C94H147N19O23
1911.31
10.10
+1
-4.37
1.544
Evidence Records 24 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml)
Evidence 2 Activity

Activity

MIC
Antibacterial
81.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.
Evidence 3 Activity

Activity

MIC
Antibacterial
48.8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against
Evidence 4 Activity

Activity

MIC
Antibacterial
18.1 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against B. cereus CGMCC 1.1846 (LC 15.33
Evidence 5 Activity

Activity

MIC
Antibacterial
90.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

uteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against B. cereus CGMCC 1.1846 (LC 15.33 uM), B. megaterium CGMCC 1.0459 (le
Evidence 6 Activity

Activity

MIC
Antibacterial
7.36 µM

Target

S. epidermidi P1111

Source & Reference

dbAMP DRAMP

Other

2.26 uM), methicillin-sensitive S. aureus CGMCC 1.89 (MIC 5.27 uM), penicillin-sensitive S. epidermidi P1111 (MIC 7.36 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 8.48 uM), MRSA P1374 (LC 6
Evidence 7 Activity

Activity

MIC
Antibacterial
8.48 µM

Target

Staphylococcus aureus p1369

Source & Reference

dbAMP DRAMP

Other

lin-sensitive S. epidermidi P1111 (MIC 7.36 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 8.48 uM), MRSA P1374 (LC 6.16 uM), penicillin-resistant S. epidermidis P1389 (LC 2.81 uM), MRSA p1
Evidence 8 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml)
Evidence 9 Activity

Activity

MIC
Antifungal
81.5 µg/mL

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.
Evidence 10 Activity

Activity

MIC
Antifungal
48.8 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against
Evidence 11 Activity

Activity

MIC
Antifungal
18.1 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against B. cereus CGMCC 1.1846 (LC 15.33
Evidence 12 Activity

Activity

MIC
Antifungal
90.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against B. cereus CGMCC 1.1846 (LC 15.33 uM), B. megaterium CGMCC 1.0459 (le
Evidence 13 Activity

Activity

MIC
Antifungal
7.36 µM

Target

S. epidermidi P1111

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2.26 uM), methicillin-sensitive S. aureus CGMCC 1.89 (MIC 5.27 uM), penicillin-sensitive S. epidermidi P1111 (MIC 7.36 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 8.48 uM), MRSA P1374 (LC 6
Evidence 14 Activity

Activity

MIC
Antifungal
8.48 µM

Target

Staphylococcus aureus p1369

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lin-sensitive S. epidermidi P1111 (MIC 7.36 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 8.48 uM), MRSA P1374 (LC 6.16 uM), penicillin-resistant S. epidermidis P1389 (LC 2.81 uM), MRSA p1
Evidence 15 Activity

Activity

MIC
Antiparasitic
16 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml)
Evidence 16 Activity

Activity

MIC
Antiparasitic
81.5 µg/mL

Target

M. luteus

Source & Reference

DRAMP

Other

Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.
Evidence 17 Activity

Activity

MIC
Antiparasitic
48.8 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against Gram+ bacteria S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against
Evidence 18 Activity

Activity

MIC
Antiparasitic
18.1 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

S. aureus (MIC 16 ug/ml), M. luteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against B. cereus CGMCC 1.1846 (LC 15.33
Evidence 19 Activity

Activity

MIC
Antiparasitic
90.8 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

DRAMP

Other

uteus (MIC 81.5 ug/ml), B. subtilis (MIC 48.8 ug/ml), Gram- E. coli (MIC 18.1 ug/ml), and P. aeruginosa (MIC 90.8 ug/ml). Also active against B. cereus CGMCC 1.1846 (LC 15.33 uM), B. megaterium CGMCC 1.0459 (le
Evidence 20 Activity

Activity

MIC
Antiparasitic
7.36 µM

Target

S. epidermidi P1111

Source & Reference

DRAMP

Other

2.26 uM), methicillin-sensitive S. aureus CGMCC 1.89 (MIC 5.27 uM), penicillin-sensitive S. epidermidi P1111 (MIC 7.36 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 8.48 uM), MRSA P1374 (LC 6
Evidence 21 Activity

Activity

MIC
Antiparasitic
8.48 µM

Target

Staphylococcus aureus p1369

Source & Reference

DRAMP

Other

lin-sensitive S. epidermidi P1111 (MIC 7.36 uM), methicillin-resistant coagulase-negative S. aureus p1369 (MIC 8.48 uM), MRSA P1374 (LC 6.16 uM), penicillin-resistant S. epidermidis P1389 (LC 2.81 uM), MRSA p1
Evidence 22 Activity

Activity

61±2.5% Hemolysis
Toxicity
3.125 µM
Hemolytic Cytotoxic
61±2.5% Hemolysis | 3.125 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 23 Activity

Activity

100% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 12.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 24 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.