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Peptide record

TPDB00455

ACE inhibitor ACE inhibitors Antihypertensive Antioxidant Bitter standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB00455
ACE inhibitor
ACE inhibitors Antihypertensive Antioxidant Bitter
Cardiometabolic peptides Food sensory peptides Functional / health-promoting peptides
Peptipedia AHTPDB Tastepeptides-Meta
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, Antioxidant, and other sources) peptide sequence curated from Peptipedia, AHTPDB, and Tastepeptides-Meta, with an available 3D structural model.
Sequence
FGF
Physicochemical Analysis
C20H23N3O4
ARNDCEQHILKMPSTWYV
F
369.42
6.02
0
0
2
-0
-2.25
1.733
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C20H23N3O4
369.42
6.02
-0
-2.25
1.733
369.4134
369.1683
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
19.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Wang X., Wang J., Lin Y., Ding Y., Wang Y., Cheng X., Lin Z.
QSAR study on Angiotensin-Converting Enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors. J. Mol. Model., 17, 1599-1606, 2011
2011
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C20H23N3O4/c21-16(11-14-7-3-1-4-8-14)19(25)22-13-18(24)23-17(20(26)27)12-15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,22,25)(H,23,24)(H,26,27)/t16-,17-/m0/s1 InChIKey=NHCKESBLOMHIIE-IRXDYDNUSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10225)
Evidence 2 Activity

Activity

IC50
Antihypertensive
19.50 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Wang X., Wang J., Lin Y., Ding Y., Wang Y., Cheng X., Lin Z.
QSAR study on Angiotensin-Converting Enzyme inhibitor oligopeptides based on a novel set of sequence information descriptors. J. Mol. Model., 17, 1599-1606, 2011
2011
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)O InChI=1S/C20H23N3O4/c21-16(11-14-7-3-1-4-8-14)19(25)22-13-18(24)23-17(20(26)27)12-15-9-5-2-6-10-15/h1-10,16-17H,11-13,21H2,(H,22,25)(H,23,24)(H,26,27)/t16-,17-/m0/s1 InChIKey=NHCKESBLOMHIIE-IRXDYDNUSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10225)
Additional Detail Fields 1 fields
3