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Peptide record

TPDB00451

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB00451
Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb dbACP Antifungipept CAFPdb AODB dbAMP 3.0 i2APP APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFSLIPSLVGGLISAFK
Physicochemical Analysis
C89H138N18O21
RNDCEQHMTWY
LFS
1796.18
10.10
1
0
10
+1
-3.94
1.535
137.65
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
2
I
3
L
1
K
0
M
3
F
1
P
3
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 1 M: 0 F: 3 P: 1 S: 3 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C89H138N18O21
1796.18
10.10
+1
-3.94
1.535
Evidence Records 9 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
0 1 1 0 1 1 3 %
[Ref.29670004]Hemolysis 0% at 1.17 µM, hemolysis 1% at 2.34 µM, hemolysis 1% at 4.69 µM, hemolysis 0% at 9.38 µM, hemolysis 1% at 18.75 µM, hemolysis 1% at 37.50 µM, hemolysis 3% at 75.00 µM against human red blood cell

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxins (Basel). 2018 Apr 18 10(4). pii: E161.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

22% Hemolysis
Toxicity
139.5 µM
Hemolytic Cytotoxic
22% Hemolysis | 139.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin. | Peptides | 2015
Evidence 3 Activity

Activity

50% Cell death
Toxicity
150 µM
Cytotoxic
50% Cell death | 150 | µM | target cell: Vero E6 cells

Target

Vero E6 cells

Source & Reference

NA
DBAASP
Structural characterization of a novel peptide with antimicrobial activity from the venom gland of the scorpion Tityus stigmurus: Stigmurin. | Peptides | 2015
Evidence 4 Activity

Activity

IC50
Toxicity
7.98 µM
Cytotoxic
IC50 | 7.98 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity. | Toxins (Basel) | 2018
Evidence 5 Activity

Activity

3% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
3% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity. | Toxins (Basel) | 2018
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
0% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico and in vitro structure-stability-function relationship of analog peptides of Stigmurin and its antibacterial and antibiofilm activities. | Pharmacol Res | 2022
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29670004]Hemolysis 0% at 1.17 µM, hemolysis 1% at 2.34 µM, hemolysis 1% at 4.69 µM, hemolysis 0% at 9.38 µM, hemolysis 1% at 18.75 µM, hemolysis 1% at 37.50 µM, hemolysis 3% at 75.00 µM against human red blood cell | Cytotoxicity: [Ref.29670004] The cell viability of HeLa cell lines is 56%, 66%, 66%, 81%, 78%, 66% and 30% at peptide concentrations of 2, 4, 8, 10, 15, 20 and 40 µM. ##The cell viability of 3T3 cell lines is 81%, 63%, 51%, 29%, 27%, 19% and 15% at peptide concentra

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2018 Apr 18 10(4). pii: E161.
Evidence 8 Activity

Activity

% Hemolysis
Toxicity
7 %
Hemolytic
Hemolytic_activity: [Ref.30709056] 7% hemolysis at 1.2 µg/ml , 4% hemolysis at 2.3 µg/ml , 2% hemolysis at 4.7 µg/ml , 0% hemolysis at 9.4 µg/ml , 3% hemolysis at 18.8 µg/ml , 2% hemolysis at 37.5 µg/ml , 3% hemolysis at 75 µg/ml , 5% hemolysis at 150 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Jan 31 20(3). pii: E623. doi: 10.3390/ijms20030623.
Evidence 9 Hemolysis

Activity

0 1 1 0 1 1 3 %
% Hemolysis
[Ref.29670004]Hemolysis 0% at 1.17 µM, hemolysis 1% at 2.34 µM, hemolysis 1% at 4.69 µM, hemolysis 0% at 9.38 µM, hemolysis 1% at 18.75 µM, hemolysis 1% at 37.50 µM, hemolysis 3% at 75.00 µM against human red blood cell
Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
Toxins (Basel). 2018 Apr 18 10(4). pii: E161.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.