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Peptide record

TPDB00446

Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB00446
Antibacterial Anticancer Antifungal Antioxidant Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFGHLFKLATKIIPSLFQ
Physicochemical Analysis
C106H159N23O22
RNDCEMWYV
F
2107.57
10.60
3
0
10
+2
-2.74
0.856
113.89
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
1
G
1
H
2
I
3
L
2
K
0
M
4
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 1 I: 2 L: 3 K: 2 M: 0 F: 4 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C106H159N23O22
2107.57
10.60
+2
-2.74
0.856
Evidence Records 7 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
74 100 %
[Ref.19088182]74% hemolytic activity at 6.25 M, 100% hemolytic activity at 12.5 M against rabbit red blood cells

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
FASEB J. 2009 Apr 23(4):1230-1245.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

75% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
75% Hemolysis | 6.25 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. | FASEB J | 2009
Evidence 3 Activity

Activity

100% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 12.5 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. | FASEB J | 2009
Evidence 4 Activity

Activity

25% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
25% Hemolysis | 25 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. | FASEB J | 2009
Evidence 5 Activity

Activity

100% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
100% Hemolysis | 12.5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs. | Front Microbiol | 2018
Evidence 6 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.19088182]74% hemolytic activity at 6.25 M, 100% hemolytic activity at 12.5 M against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
FASEB J. 2009 Apr 23(4):1230-1245.
Evidence 7 Hemolysis

Activity

74 100 %
% Hemolysis
[Ref.19088182]74% hemolytic activity at 6.25 M, 100% hemolytic activity at 12.5 M against rabbit red blood cells
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
FASEB J. 2009 Apr 23(4):1230-1245.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.