TPDB

3D PDB MODEL

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TPDB ID TPDB00441

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

FEQI

FASTA

>TPDB00441|ACE inhibitors;Antioxidant|length=4
FEQI

Formula C25H37N5O8

Absent Amino Acids ARNDCGHLKMPSTWYV

Common Amino Acids EQIF

Mass 535.60

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -1

Boman Index 1.16

Hydrophobicity 0.075

Aliphatic Index 97.50

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

1

E

1

Q

0

G

0

H

1

I

0

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

4

Formula

C25H37N5O8

Mass

535.60

PI

3.29

Net Charge

-1

Boman Index

1.16

Hydrophobicity

0.075

Chemical_Mass

535.5885

Monoisotopic_Mass

535.2633

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Girgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.

Title

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384–394.

Year 2014

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])([C@]([H])(CC)C)C(=O)O InChI= 1S/C25H37N5O8/c1-3-14(2)21(25(37)38)30-24(36)17(9-11-19(27)31)29-23(35)18(10-12-20(32)33)28-22(34)16(26)13-15-7-5-4-6-8-15/h4-8,14,16-18,21H,3,9-13,26H2,1-2H3,(H2,27,31)(H,28,34)(H,29,35)(H,30,36)(H,32,33)(H,37,38)/t14-,16-,17-,18-,21-/m0/s1 InChIKey: KCESGKFGKHGQDT-KDBGDGBXSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9980) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9982)

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Number_of_Residues

4