TPDB

3D PDB MODEL

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TPDB ID TPDB00432

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 6-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AODB, AoXpDb, and other sources, with an available 3D structural model.

Sequence

FDPFPK

FASTA

>TPDB00432|ACE inhibitors;Antioxidant|length=6
FDPFPK

Formula C38H51N7O9

Absent Amino Acids ARNCEQGHILMSTWYV

Common Amino Acids FP

Mass 749.86

PI 6.75

Basic Residues 1

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -0

Boman Index 0.86

Hydrophobicity -0.833

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

1

K

0

M

2

F

2

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

6

Formula

C38H51N7O9

Mass

749.86

PI

6.75

Net Charge

-0

Boman Index

0.86

Hydrophobicity

-0.833

Chemical_Mass

749.8510

Monoisotopic_Mass

749.3736

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 105.75 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Zielińska E., Karaś M., Baraniak B., Jakubczyk A.

Title

Evaluation of ACE, alpha‑glucosidase, and lipase inhibitory activities of peptides obtained by in vitro digestion of selected species of edible insects. Eur. Food Res. Technol., 246, 1361-1369, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 6

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(CC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@H](CC1=CC=C(C=C1))C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C38H51N7O9/c39-18-8-7-15-27(38(53)54)41-34(49)30-16-9-19-44(30)36(51)28(22-25-13-5-2-6-14-25)43-35(50)31-17-10-20-45(31)37(52)29(23-32(46)47)42-33(48)26(40)21-24-11-3-1-4-12-24/h1-6,11-14,26-31H,7-10,15-23,39-40H2,(H,41,49)(H,42,48)(H,43,50)(H,46,47)(H,53,54)/t26-,27-,28-,29-,30-,31-/m0/s1 InChIKey=DYMKEWHUWRCOCQ-HPMAGDRPSA-N Inhibitor of pancreatic lipase according to the BIOPEP-UWM database of bioactive peptides (ID 9844) Inhibitor of Alpha-glucosidase (EC 3.2.1.20) according to the BIOPEP-UWM database of bioactive peptides (ID 9845) Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9446)

Number_of_Residues

6