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Peptide record

TPDB00421

Salamandrin - I Anticancer Antioxidant standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB00421
Salamandrin - I
Anticancer Antioxidant
Cancer-related peptides Functional / health-promoting peptides
CancerPPD 2.0 AoXpDb
standard
No
A 12-aa standard natural multi-activity (Anticancer and Antioxidant) peptide sequence curated from CancerPPD 2.0 and AoXpDb, with an available 3D structural model.
C-terminal: Amidation
Sequence
FAVWGCADYRGY-NH2
Physicochemical Analysis
C66H86N16O17S1
NEQHILKMPST
AGY
1407.57
6.08
1
1
7
-0
-3.31
0.067
40.83
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
8480
602.46
3
Residue Composition
number
2
A
1
R
0
N
1
D
1
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
12
C66H86N16O17S1
1407.57
6.08
-0
-3.31
0.067
Amidation
L
Linear
Free
Antioxidant
Salamandra salamandra
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
IC50 = 27 µM
Anticancer
27 µM

Target

Leukemia Cancer
HL-60
Blood

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2023

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

Absorbance
Absorbance ~ 2 at 490 nm at 27 27 µM
Anticancer
~2

Target

Leukemia Cancer
HL-60
Blood

Assay & Model

LDH leakage assay
48-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2023