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Peptide record

TPDB00419

ACE inhibitor from alphas2-CN (174-181) ACE inhibitors Antihypertensive Antioxidant standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB00419
ACE inhibitor from alphas2-CN (174-181)
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
FermFooDB pep-lab Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 8-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from FermFooDB, pep-lab, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FALPQYLK
Physicochemical Analysis
C49H74N10O11
RNDCEGHIMSTWV
L
979.19
9.74
1
0
5
+1
-1.34
0.237
110.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
152.17
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
1
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
8
C49H74N10O11
979.19
9.74
+1
-1.34
0.237
979.1693
978.5521
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
4.30 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001).
ACE inhibitor
ah

Source & Reference

FermFooDB
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C49H74N10O11/c1-28(2)24-37(45(65)55-36(49(69)70)14-9-10-22-50)56-46(66)38(27-32-16-18-33(60)19-17-32)57-44(64)35(20-21-41(52)61)54-47(67)40-15-11-23-59(40)48(68)39(25-29(3)4)58-42(62)30(5)53-43(63)34(51)26-31-12-7-6-8-13-31/h6-8,12-13,16-19,28-30,34-40,60H,9-11,14-15,20-27,50-51H2,1-5H3,(H2,52,61)(H,53,63)(H,54,67)(H,55,65)(H,56,66)(H,57,64)(H,58,62)(H,69,70)/t30-,34-,35-,36-,37-,38-,39-,40-/m0/s1 InChIKey=AIBFLFDJKNLEHK-FTSPKJONSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8151) the DFBP database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 387) the EROP-Moscow database Predicted antithrombotic peptide according to the BIOPEP-UWM Virtual database (ID 215)
Evidence 2 Activity

Activity

IC50
Antihypertensive
4.30 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001).
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Meisel H., Walsh D. J., Murray B., FitzGerald R. J.
ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006
2006
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
8
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CC(C)C)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C49H74N10O11/c1-28(2)24-37(45(65)55-36(49(69)70)14-9-10-22-50)56-46(66)38(27-32-16-18-33(60)19-17-32)57-44(64)35(20-21-41(52)61)54-47(67)40-15-11-23-59(40)48(68)39(25-29(3)4)58-42(62)30(5)53-43(63)34(51)26-31-12-7-6-8-13-31/h6-8,12-13,16-19,28-30,34-40,60H,9-11,14-15,20-27,50-51H2,1-5H3,(H2,52,61)(H,53,63)(H,54,67)(H,55,65)(H,56,66)(H,57,64)(H,58,62)(H,69,70)/t30-,34-,35-,36-,37-,38-,39-,40-/m0/s1 InChIKey=AIBFLFDJKNLEHK-FTSPKJONSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 8151) the DFBP database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids (ID 387) the EROP-Moscow database Predicted antithrombotic peptide according to the BIOPEP-UWM Virtual database (ID 215)
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb FermFooDB
DFBP
Additional Detail Fields 1 fields
8