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Peptide record

TPDB00362

Anti-inflammatory Antibacterial Anticancer Antifungal Antioxidant Toxicity standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB00362
Anti-inflammatory Antibacterial Anticancer Antifungal Antioxidant Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides Functional / health-promoting peptides
Peptipedia AntiBP3 CAFPdb dbAMP AODB ToxinPred 3.0
standard
No
A 29-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, AntiBP3, CAFPdb, and other sources, with an available 3D structural model.
Sequence
EGCNILCLLKRKVKAVKNVVKNVVKSVVG
Physicochemical Analysis
C139H253N41O36S2
DQHMFPTWY
V
3138.91
10.54
7
1
13
+6
8.10
0.441
137.24
Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour
125
3.98
6
Residue Composition
number
1
A
1
R
3
N
0
D
2
C
1
E
0
Q
2
G
0
H
1
I
3
L
6
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
8
V
Amino Acid Distribution
A: 1 R: 1 N: 3 D: 0 C: 2 E: 1 Q: 0 G: 2 H: 0 I: 1 L: 3 K: 6 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 8
Chemical Descriptors
29
C139H253N41O36S2
3138.91
10.54
+6
8.10
0.441
Evidence Records 22 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6 µM

Target

S. castellani ATCC12022

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli CMCC44102, S. castellani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 u
Evidence 2 Activity

Activity

MIC
Antibacterial
3 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Active against Gram- E. coli CMCC44102, S. castellani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (M
Evidence 3 Activity

Activity

MIC
Antibacterial
3 µM

Target

V. parahaemolyticus

Source & Reference

dbAMP

Other

am- E. coli CMCC44102, S. castellani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (MIC 23.9 uM), (inactive) P.aerugi
Evidence 4 Activity

Activity

MIC
Antibacterial
11.9 µM

Target

A. hydrophila

Source & Reference

dbAMP

Other

lani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (MIC 23.9 uM), (inactive) P.aeruginosa CMCC10104, K.pneumoniae,
Evidence 5 Activity

Activity

MIC
Antibacterial
23.9 µM

Target

V. splendidus

Source & Reference

dbAMP

Other

25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (MIC 23.9 uM), (inactive) P.aeruginosa CMCC10104, K.pneumoniae, A.sobria, V.alginolyticu, V.vulnificus,
Evidence 6 Activity

Activity

MIC
Antibacterial
3 µM

Target

Staphylococcus aureus CMCC26003

Source & Reference

dbAMP

Other

niae, A.sobria, V.alginolyticu, V.vulnificus, A.baumnnii (MIC all >100 uM) Gram+ active: S. aureus CMCC26003 (MIC 3 uM), C. perfringens ATCC13124, B. subtilis CMCC63501 (MIC 11.9 uM), inactive: B.cereus CMCC63
Evidence 7 Activity

Activity

MIC
Antibacterial
11.9 µM

Target

B. subtilis CMCC63501

Source & Reference

dbAMP

Other

MIC all >100 uM) Gram+ active: S. aureus CMCC26003 (MIC 3 uM), C. perfringens ATCC13124, B. subtilis CMCC63501 (MIC 11.9 uM), inactive: B.cereus CMCC63301, E.faecalis ATCC29212, S.epidermidis, E.faecium (MIC >100 u
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

E.faecium

Source & Reference

dbAMP

Other

CC63501 (MIC 11.9 uM), inactive: B.cereus CMCC63301, E.faecalis ATCC29212, S.epidermidis, E.faecium (MIC >100 uM), fungi C.albicans and C.glabrata (MIC >100 uM). Reg. 7/2021
Evidence 9 Activity

Activity

MIC
Antibacterial
>100 µM

Target

C.glabrata

Source & Reference

dbAMP

Other

63301, E.faecalis ATCC29212, S.epidermidis, E.faecium (MIC >100 uM), fungi C.albicans and C.glabrata (MIC >100 uM). Reg. 7/2021
Evidence 10 Activity

Activity

MIC
Antifungal
6 µM

Target

S. castellani ATCC12022

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli CMCC44102, S. castellani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 u
Evidence 11 Activity

Activity

MIC
Antifungal
3 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb

Other

Active against Gram- E. coli CMCC44102, S. castellani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (M
Evidence 12 Activity

Activity

MIC
Antifungal
3 µM

Target

V. parahaemolyticus

Source & Reference

dbAMP CAFPdb

Other

am- E. coli CMCC44102, S. castellani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (MIC 23.9 uM), (inactive) P.aerugi
Evidence 13 Activity

Activity

MIC
Antifungal
11.9 µM

Target

A. hydrophila

Source & Reference

dbAMP CAFPdb

Other

lani ATCC12022 (MIC 6 uM), E. coli ATCC 25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (MIC 23.9 uM), (inactive) P.aeruginosa CMCC10104, K.pneumoniae,
Evidence 14 Activity

Activity

MIC
Antifungal
23.9 µM

Target

V. splendidus

Source & Reference

dbAMP CAFPdb

Other

25922 (MIC 3 uM), V. parahaemolyticus (MIC 3 uM), A. hydrophila (MIC 11.9 uM), V. Harvey, V. splendidus (MIC 23.9 uM), (inactive) P.aeruginosa CMCC10104, K.pneumoniae, A.sobria, V.alginolyticu, V.vulnificus,
Evidence 15 Activity

Activity

MIC
Antifungal
3 µM

Target

Staphylococcus aureus CMCC26003

Source & Reference

dbAMP CAFPdb

Other

niae, A.sobria, V.alginolyticu, V.vulnificus, A.baumnnii (MIC all >100 uM) Gram+ active: S. aureus CMCC26003 (MIC 3 uM), C. perfringens ATCC13124, B. subtilis CMCC63501 (MIC 11.9 uM), inactive: B.cereus CMCC63
Evidence 16 Activity

Activity

MIC
Antifungal
11.9 µM

Target

B. subtilis CMCC63501

Source & Reference

dbAMP CAFPdb

Other

MIC all >100 uM) Gram+ active: S. aureus CMCC26003 (MIC 3 uM), C. perfringens ATCC13124, B. subtilis CMCC63501 (MIC 11.9 uM), inactive: B.cereus CMCC63301, E.faecalis ATCC29212, S.epidermidis, E.faecium (MIC >100 u
Evidence 17 Activity

Activity

MIC
Antifungal
>100 µM

Target

E.faecium

Source & Reference

dbAMP CAFPdb

Other

CC63501 (MIC 11.9 uM), inactive: B.cereus CMCC63301, E.faecalis ATCC29212, S.epidermidis, E.faecium (MIC >100 uM), fungi C.albicans and C.glabrata (MIC >100 uM). Reg. 7/2021
Evidence 18 Activity

Activity

MIC
Antifungal
>100 µM

Target

C.glabrata

Source & Reference

dbAMP CAFPdb

Other

63301, E.faecalis ATCC29212, S.epidermidis, E.faecium (MIC >100 uM), fungi C.albicans and C.glabrata (MIC >100 uM). Reg. 7/2021
Evidence 19 Activity

Activity

7.5% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
7.5% Hemolysis | 200 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Identification and characterization of novel bi-functional cathelicidins from the black-spotted frog (Pelophylax nigromaculata) with both anti-infective and antioxidant activities. | Dev Comp Immunol | 2021
Evidence 20 Activity

Activity

35.4% Killing
Toxicity
200 µg/mL
Cytotoxic
35.4% Killing | 200 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Identification and characterization of novel bi-functional cathelicidins from the black-spotted frog (Pelophylax nigromaculata) with both anti-infective and antioxidant activities. | Dev Comp Immunol | 2021
Evidence 21 Activity

Activity

19.2% Killing
Toxicity
200 µg/mL
Cytotoxic
19.2% Killing | 200 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Identification and characterization of novel bi-functional cathelicidins from the black-spotted frog (Pelophylax nigromaculata) with both anti-infective and antioxidant activities. | Dev Comp Immunol | 2021
Evidence 22 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Dev Comp Immunol. 2021 Mar 116:103929.