TPDB

3D PDB MODEL

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TPDB ID TPDB00359

Peptide_Name

ACE inhibitor

Activity

ACE inhibitors Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

Peptipedia AnOxPePred - 1.0 AODB Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 4-aa standard natural multi-activity (ACE inhibitors and Antioxidant) peptide sequence curated from Peptipedia, AnOxPePred - 1.0, AODB, and other sources, with an available 3D structural model.

Sequence

EFLQ

FASTA

>TPDB00359|ACE inhibitors;Antioxidant|length=4
EFLQ

Formula C25H37N5O8

Absent Amino Acids ARNDCGHIKMPSTWYV

Common Amino Acids EQLF

Mass 535.60

PI 3.29

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 2

Net Charge -1

Boman Index 0.91

Hydrophobicity -0.100

Aliphatic Index 97.50

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

0

A

0

R

0

N

0

D

0

C

1

E

1

Q

0

G

0

H

0

I

1

L

0

K

0

M

1

F

0

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

4

Formula

C25H37N5O8

Mass

535.60

PI

3.29

Net Charge

-1

Boman Index

0.91

Hydrophobicity

-0.100

Chemical_Mass

535.5885

Monoisotopic_Mass

535.2633

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity ACE inhibitors

Activity Measurement 0.00 µM

Function Inhibitor of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source NA

Authors Girgih AT, He R, Malomo SA, Offengenden M, Wu J, Aluko RE.

Title

Structural and functional characterization of hemp seed (Cannabis sativa L.) protein-derived antioxidant and antihypertensive peptides. J. Funct. Foods 6, 384–394.

Year 2014

Literature Source Journal

Other

Number of Residues 4

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(Cc1ccccc1)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI= 1S/C25H37N5O8/c1-14(2)12-18(23(35)28-17(25(37)38)9-10-20(27)31)30-24(36)19(13-15-6-4-3-5-7-15)29-22(34)16(26)8-11-21(32)33/h3-7,14,16-19H,8-13,26H2,1-2H3,(H2,27,31)(H,28,35)(H,29,34)(H,30,36)(H,32,33)(H,37,38)/t16-,17-,18-,19-/m0/s1 InChIKey: XFHRZKLZXVCJNL-VJANTYMQSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9971) Inhibitor of Renin (EC 3.4.23.15) (MEROPS ID A01.007) according to the BIOPEP-UWM database of bioactive peptides (ID 9973)

Evidence 2 Activity

Activity

Main Bioactivity Antioxidative activity

Detail Source Activity Antioxidant

Source & Reference

Database Source AODB

Source DFBP

Number_of_Residues

4