TPDB

3D PDB MODEL

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TPDB ID TPDB00338

Peptide_Name

Anti-inflammatory peptide

Activity

Anti-inflammatory Antioxidant

Activity_category_statistics

Immunity and inflammation peptides Functional / health-promoting peptides

Database_Source

Peptipedia AODB AoXpDb

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Anti-inflammatory and Antioxidant) peptide sequence curated from Peptipedia, AODB, and AoXpDb, with an available 3D structural model.

Sequence

EDDQMDPMAK

FASTA

>TPDB00338|Anti-inflammatory;Antioxidant|length=10
EDDQMDPMAK

Formula C46H74N12O20S2

Absent Amino Acids RNCGHILFSTWYV

Common Amino Acids D

Mass 1179.28

PI 3.50

Basic Residues 1

Acidic Residues 4

Hydrophobic Residues 3

Net Charge -3

Boman Index 7.10

Hydrophobicity -1.740

Aliphatic Index 10.00

Half Life

Mammalian: 1 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

1

A

0

R

0

N

3

D

0

C

1

E

1

Q

0

G

0

H

0

I

0

L

1

K

2

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 3 C: 0 E: 1 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 1 M: 2 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

10

Formula

C46H74N12O20S2

Mass

1179.28

PI

3.50

Net Charge

-3

Boman Index

7.10

Hydrophobicity

-1.740

Chemical_Mass

1179.2774

Monoisotopic_Mass

1178.4566

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Anti-inflammatory

Activity Measurement 0.00 µM

Detail Activity anti inflammatory

Activity Code ai

Source & Reference

Database Source NA

Authors Hu S., Yuan J., Gao J., Wu Y., Meng X., Tong P., Chen H.

Title

Antioxidant and Anti-Inflammatory Potential of Peptides Derived from In Vitro Gastrointestinal Digestion of Germinated and Heat-Treated Foxtail Millet (Setaria italica) Proteins, J. Agric. Food Chem., 68(35), 9415–9426, 2020

Year 2020

Literature Source Journal

Other

Number of Residues 10

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CCC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(CC(=O)O)C(=O)N1[C@@]([H])(CCC1)C(=O)N[C@@]([H])(CCSC)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C46H74N12O20S2/c1-22(37(68)54-27(46(77)78)7-4-5-15-47)50-39(70)25(13-17-79-2)53-44(75)31-8-6-16-58(31)45(76)30(21-36(66)67)57-41(72)26(14-18-80-3)52-40(71)24(10-11-32(49)59)51-42(73)29(20-35(64)65)56-43(74)28(19-34(62)63)55-38(69)23(48)9-12-33(60)61/h22-31H,4-21,47-48H2,1-3H3,(H2,49,59)(H,50,70)(H,51,73)(H,52,71)(H,53,75)(H,54,68)(H,55,69)(H,56,74)(H,57,72)(H,60,61)(H,62,63)(H,64,65)(H,66,67)(H,77,78)/t22-,23-,24-,25-,26-,27-,28-,29-,30-,31-/m0/s1 InChIKey: UMJCJMWDIKSQQL-ACNOIZITSA-N

Number_of_Residues

10