TPDB

3D PDB MODEL

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TPDB ID TPDB00315

Peptide_Name

ACE inhibitor

Activity

Antihypertensive Antioxidant

Activity_category_statistics

Cardiometabolic peptides Functional / health-promoting peptides

Database_Source

AHTPDB AHTpin Peptipedia AnOxPePred - 1.0 Multi-AOP

Sequence_Type

standard

Has_Modification No

Description A 2-aa standard natural multi-activity (Antihypertensive and Antioxidant) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.

Sequence

DW

FASTA

>TPDB00315|Antihypertensive;Antioxidant|length=2
DW

Formula C15H17N3O5

Absent Amino Acids ARNCEQGHILKMFPSTYV

Common Amino Acids DW

Mass 319.32

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 1

Net Charge -1

Boman Index -0.62

Hydrophobicity -2.200

Aliphatic Index 0.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 1722.43

Polar Residues 0

number

0

A

0

R

0

N

1

D

0

C

0

E

0

Q

0

G

0

H

0

I

0

L

0

K

0

M

0

F

0

P

0

S

0

T

1

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0

Length

2

Formula

C15H17N3O5

Mass

319.32

PI

3.10

Net Charge

-1

Boman Index

-0.62

Hydrophobicity

-2.200

Chemical_Mass

319.3119

Monoisotopic_Mass

319.1164

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antihypertensive

Activity Measurement 258.00 µM

Function Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)

Detail Activity ACE inhibitor

Activity Code ah

Source & Reference

Database Source AHTPDB

Authors Norris R., Casey F., FitzGerald R. J., Shields D., Mooney C.

Title Predictive modelling of angiotensin converting enzyme inhibitory dipeptides. Food Chem., 133, 1349-1354, 2012

Year 2012

Literature Source Journal

Other

Source Activity Label	Source Definition
Antihypertensive	AHTPDB manually curated experimentally validated antihypertensive peptide annotation.

Number of Residues 2

Additional Info

BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)O)C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C15H17N3O5/c16-10(6-13(19)20)14(21)18-12(15(22)23)5-8-7-17-11-4-2-1-3-9(8)11/h1-4,7,10,12,17H,5-6,16H2,(H,18,21)(H,19,20)(H,22,23)/t10-,12-/m0/s1 InChIKey=ZARXTZFGQZBYFO-JQWIXIFHSA-N Bitterness suppressing peptide according to the BIOPEP-UWM Virtual database (ID 134)

Number_of_Residues

2