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Peptide record

TPDB00300

Angiotensin I Antihypertensive Antioxidant Blood-Brain Barrier Neuropeptide standard

10 amino acids

3D PDB MODEL

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TPDB ID TPDB00300

Peptide_Name

Angiotensin I

Activity

Antihypertensive Antioxidant Blood-Brain Barrier Neuropeptide

Activity_category_statistics

Cardiometabolic peptides Delivery and barrier-penetrating peptides Neuroactive peptides Functional / health-promoting peptides

Database_Source

AHTPDB AHTpin Peptipedia AnOxPePred - 1.0 AODB AoXpDb Multi-AOP B3Pred BBPpredict

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antihypertensive, Antioxidant, Blood-Brain Barrier, and other sources) peptide sequence curated from AHTPDB, AHTpin, Peptipedia, and other sources, with an available 3D structural model.

Sequence

DRVYIHPFHL

FASTA

>TPDB00300|Antihypertensive;Antioxidant;Blood-Brain Barrier;Neuropeptide|length=10
DRVYIHPFHL

Formula C62H89N17O14

Absent Amino Acids ANCEQGKMSTW

Common Amino Acids H

Mass 1296.49

PI 7.92

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 5

Net Charge +0

Boman Index 1.54

Hydrophobicity -0.200

Aliphatic Index 107.00

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 114.93

Polar Residues 1

number

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 1

Length

Formula

C62H89N17O14

Mass

1296.49

7.92

Net Charge

Boman Index

1.54

Hydrophobicity

-0.200

Conformation

Linear

Peptide_Length

Similarity

Peptide_Sequence_3Letter

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

SMILES

O=C(O)CC(N)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3C(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CC(C)C)Cc1cncn1)Cc2ccccc2)CCC3)Cc4cncn4)C(C)CC)Cc5ccc(O)cc5)C(C)C)CCCNC(=[N@H])N

Evidence 1 Activity

Activity

Detail Source Activity Blood-Brain Barrier

Assay & Model

Animal Model Origin/Source

Source & Reference

Database Source NA

Source B3Pdb

Organism Source Ovis aries

Family Serpin

Family

Serpin