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Peptide record

TPDB00182

Antibacterial Antifungal Antioxidant Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB00182
Antibacterial Antifungal Antioxidant Toxicity
Anti-infective peptides Toxicity and safety peptides Functional / health-promoting peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Antifungal, Antioxidant, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
CARLNCVPKGTSGNTETCPCYASLHSCRKYG
Physicochemical Analysis
C136H219N43O44S5
DQIMFW
C
3320.80
8.46
5
1
7
+3
4.69
-0.455
40.97
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
3230
97.27
15
Residue Composition
number
2
A
2
R
2
N
0
D
5
C
1
E
0
Q
3
G
1
H
0
I
2
L
2
K
0
M
0
F
2
P
3
S
3
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 0 C: 5 E: 1 Q: 0 G: 3 H: 1 I: 0 L: 2 K: 2 M: 0 F: 0 P: 2 S: 3 T: 3 W: 0 Y: 2 V: 1
Chemical Descriptors
31
C136H219N43O44S5
3320.80
8.46
+3
4.69
-0.455
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
7.65 ug/mL

Target

P. azadirachtae PTCC5027

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Lehrer's radial diffusion assay: Active against P. azadirachtae PTCC5027 (MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PT
Evidence 2 Activity

Activity

MIC
Antibacterial
28.8 µg/mL

Target

Staphylococcus aureus PTCC1442

Source & Reference

dbAMP

Other

ehrer's radial diffusion assay: Active against P. azadirachtae PTCC5027 (MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis
Evidence 3 Activity

Activity

MIC
Antibacterial
13.6 µg/mL

Target

Escherichia coli PTCC2433

Source & Reference

dbAMP

Other

e against P. azadirachtae PTCC5027 (MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3
Evidence 4 Activity

Activity

MIC
Antibacterial
14.1 µg/mL

Target

Klebsiella pneumoniae PTCC4231

Source & Reference

dbAMP

Other

(MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 u
Evidence 5 Activity

Activity

MIC
Antibacterial
24.2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP

Other

28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021
Evidence 6 Activity

Activity

MIC
Antibacterial
9.3 µg/mL

Target

A. niger

Source & Reference

dbAMP

Other

(MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021 (MIC 8.36 ug/ml). Snakin-
Evidence 7 Activity

Activity

MIC
Antibacterial
8.23 µg/mL

Target

Candida albicans PTCC4236

Source & Reference

dbAMP

Other

moniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021 (MIC 8.36 ug/ml). Snakin-Z also displayed antioxidant activity a
Evidence 8 Activity

Activity

MIC
Antibacterial
8.36 µg/mL

Target

P. ultimum PTCC5021

Source & Reference

dbAMP

Other

is (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021 (MIC 8.36 ug/ml). Snakin-Z also displayed antioxidant activity and is an enzyme inhibitor of acetylcholine
Evidence 9 Activity

Activity

MIC
Antifungal
7.65 ug/mL

Target

P. azadirachtae PTCC5027

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Lehrer's radial diffusion assay: Active against P. azadirachtae PTCC5027 (MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PT
Evidence 10 Activity

Activity

MIC
Antifungal
28.8 µg/mL

Target

Staphylococcus aureus PTCC1442

Source & Reference

dbAMP CAFPdb Antifungipept

Other

ehrer's radial diffusion assay: Active against P. azadirachtae PTCC5027 (MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis
Evidence 11 Activity

Activity

MIC
Antifungal
13.6 µg/mL

Target

Escherichia coli PTCC2433

Source & Reference

dbAMP CAFPdb Antifungipept

Other

e against P. azadirachtae PTCC5027 (MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3
Evidence 12 Activity

Activity

MIC
Antifungal
14.1 µg/mL

Target

Klebsiella pneumoniae PTCC4231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 7.65 ug/mL), S. aureus PTCC1442 (MIC 28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 u
Evidence 13 Activity

Activity

MIC
Antifungal
24.2 µg/mL

Target

B. subtilis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

28.8 ug/ml), E. coli PTCC2433 (MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021
Evidence 14 Activity

Activity

MIC
Antifungal
9.3 µg/mL

Target

A. niger

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 13.6 ug/ml), K. pneumoniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021 (MIC 8.36 ug/ml). Snakin-
Evidence 15 Activity

Activity

MIC
Antifungal
8.23 µg/mL

Target

Candida albicans PTCC4236

Source & Reference

dbAMP CAFPdb Antifungipept

Other

moniae PTCC4231 (MIC 14.1 ug/ml), B. subtilis (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021 (MIC 8.36 ug/ml). Snakin-Z also displayed antioxidant activity a
Evidence 16 Activity

Activity

MIC
Antifungal
8.36 µg/mL

Target

P. ultimum PTCC5021

Source & Reference

dbAMP CAFPdb Antifungipept

Other

is (MIC 24.2 ug/ml), A. niger (MIC 9.3 ug/ml), C. albicans PTCC4236 (MIC 8.23 ug/ml), and P. ultimum PTCC5021 (MIC 8.36 ug/ml). Snakin-Z also displayed antioxidant activity and is an enzyme inhibitor of acetylcholine
Evidence 17 Activity

Activity

0% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigation of the antimicrobial activities of Snakin-Z, a new cationic peptide derived from Zizyphus jujuba fruits. | Nat Prod Res | 2013