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Peptide record

TPDB00174

ACE inhibitor from bovine alphas1-CN (143-149) ACE inhibitors Antihypertensive Antioxidant standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB00174
ACE inhibitor from bovine alphas1-CN (143-149)
ACE inhibitors Antihypertensive Antioxidant
Cardiometabolic peptides Functional / health-promoting peptides
Peptipedia AHTPDB AHTpin AnOxPePred - 1.0 AODB AoXpDb Multi-AOP
standard
No
A 7-aa standard natural multi-activity (ACE inhibitors, Antihypertensive, and Antioxidant) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
AYFYPEL
Physicochemical Analysis
C46H59N7O12
RNDCQGHIKMSTWV
Y
902.01
3.29
0
1
5
-1
-1.27
0.100
70.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
2980
330.37
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
1
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
7
C46H59N7O12
902.01
3.29
-1
-1.27
0.100
901.9980
901.4207
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
6.58 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Stuknyte M., Cattaneo S., Masotti F., De Noni I.
Occurrence and fate of ACE-inhibitor peptides in cheeses and in their digestates following in vitro static gastrointestinal digestion. Food Chemistry, 168, 27-33.
2015
Journal

Other

7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N4[C@@H](CCC4)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C46H59N7O12/c1-26(2)22-37(46(64)65)52-41(59)33(19-20-39(56)57)48-44(62)38-10-7-21-53(38)45(63)36(25-30-13-17-32(55)18-14-30)51-43(61)35(23-28-8-5-4-6-9-28)50-42(60)34(49-40(58)27(3)47)24-29-11-15-31(54)16-12-29/h4-6,8-9,11-18,26-27,33-38,54-55H,7,10,19-25,47H2,1-3H3,(H,48,62)(H,49,58)(H,50,60)(H,51,61)(H,52,59)(H,56,57)(H,64,65)/t27-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey=OVPWZIOKYPAYJR-XZUOCMGYSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9175) the MBPDB database Peptide stimulating mucin secretion according to the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
6.58 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Stuknyte M., Cattaneo S., Masotti F., De Noni I.
Occurrence and fate of ACE-inhibitor peptides in cheeses and in their digestates following in vitro static gastrointestinal digestion. Food Chemistry, 168, 27-33.
2015
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
7
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N4[C@@H](CCC4)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O InChI=1S/C46H59N7O12/c1-26(2)22-37(46(64)65)52-41(59)33(19-20-39(56)57)48-44(62)38-10-7-21-53(38)45(63)36(25-30-13-17-32(55)18-14-30)51-43(61)35(23-28-8-5-4-6-9-28)50-42(60)34(49-40(58)27(3)47)24-29-11-15-31(54)16-12-29/h4-6,8-9,11-18,26-27,33-38,54-55H,7,10,19-25,47H2,1-3H3,(H,48,62)(H,49,58)(H,50,60)(H,51,61)(H,52,59)(H,56,57)(H,64,65)/t27-,33-,34-,35-,36-,37-,38-/m0/s1 InChIKey=OVPWZIOKYPAYJR-XZUOCMGYSA-N Antioxidative peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9175) the MBPDB database Peptide stimulating mucin secretion according to the MBPDB database
Evidence 3 Activity

Activity

Antioxidative activity
Antioxidant

Source & Reference

AODB AoXpDb
DFBP
Additional Detail Fields 1 fields
7